A. zileuton B. pemirolast C. ibudilast D. zafirlukast E. montelukast

44. Which of the following statements about acetazolamide is WRONG？ A. diuretic action

B. depresss the intracranial pressure C. acidify blood 10

D. alkalized urine E. hyperkalemia

45. Which of the following drugs could promote macrophage production and enhance the

nonspecific immunologic function A. erythropoietin B. thrombopoietin C. MCSF D. MultiCSF E. GCSF

46. Which of the following can be used for megaloblastic anemia A. folic acid

B. folic acid +VitB12 C. folic acid +VitB6

D. folic acid +VitB12 +VitB6

E. folic acid +VitB12+VitB6+VitC 47. All of the following are true about hydrochlorothiazide EXCEPT

A. It can be used to treat hypercalcinuria B. It can lead to hypoglycemia

C. It can increase the secretion of K + then cause hypokalemia

D. It can decrease blood pressure mildly E. It can decrease the urinary output of diabetes insipidus patients

48. Which of the statements about thiourea is WRONG?

A. They inhibit synthesis of thyroxine B. They have immunosuppressive effect C. Propylthiouracil stimulates T4 transform to T3 D. They can cause thyroid enlargement when long term used

E. They can excrete from milk and pass through placenta barrier

49. The antibiotics which are potent against the pseudomonas aeruginosa are

A. carbenicillin, polymyxin, gentamycin and tobramycine

B. kanamycin, tobramycine, polymyxin and erythromycin

C. amikacin, gentamycin, polymyxin and oxacillin

D. amikacin, gentamycin, chloramphenicol and spectinomycin

E. carbenicillin, ampicillin, Cephalexin and polymyxin

50. Which of the following compatibility administration is correct? A. streptomycin + gentamicin B. penicillin + gentamicin C. streptomycin + furosemide D. penicillin + tetracycline

E. penicillin + chloramphenicol 51．Clavulanic acid can inhibit which one of the following enzymes? 11

A．Dihydrofolate synthetase B．peptidoglycan synthetase C．βlactamase

D．DNA polymerase

E．dihydrofolate reductase

52．The agent which can relieve AIDS and AIDS correlating syndrome is A. idoxuridine B. zidovudine C. acyclovir D. ribavirin

E. adenine arabinoside

53．Which of the following imidazoles have NO effect on fungus ? A. metronidazole B. miconazole C. clotrimazole D. fluconazol

E. ketoconazole

54．Herxheimer reaction is caused by penicillin when it is used to treat： A．lobar pneumonia B．tetanus

C．viridans endocarditis D．bacterial meningitis E．leptospirosis

55. Of the following, which is the best agent to use in pregnant patient with urinary tract

infection (UTI ) caused by Chlamydia trachomatis? A. tetracycline B. levofloxacin C. gentamycin D. erythromycin E. SMZTMP

56. The t1/2 of which of the following

tetracyclines remains unchanged when the drug is

administered to an anuric patient A. methacycline B. oxytetracycline C. doxycycline D. tetracycline

E. none of the above 57. A 45yearold

female being treated for a chronic UTI develops acute alcohol intolerance.

Which of the following agents could have caused this intolerance? A. cefoperazone 12

B. amoxicillin C. SMZ

D. norfloxacin E. tetracycline

58. A patient with a pneumonia has a sputum culture that is positive for a staphylococcal

strain that is blactamase positive. Which is the best choice of penicillin therapy in this patient? A. ampicillin B. oxacillin C. penicillin V D. penicillin G E. carbenicillin 59. A 75 year old

woman is hospitalized for pneumonia and treated with an intravenous

antibiotic. On day three, she develops severe diarrhea. Stool is positive for Clostridium

difficile toxin. What is the best treatment? A. clindamycin B. cefaclor

C. metronidazole D. erythromycin E. doxycycline

60. The mechanism of action of

chloramphenicol as an antibiotic is that it A. binds to the 30s ribosome subunit B. binds to the 50s ribosome subunit C. prevents cell membrane development D. inhibits cell wall synthesis

E. inhibits RNA polymerase

Type X choice questions (one or more answers are correct)

1. If the plasma concentration of a drug declines with “first order kinetics”, it means that

A. There is only one metabolic path for drug disposition B. The half life

is the same regardless of plasma concentration

C. The drug is largely metabolized in the liver after oral administration and has low bioavailability

D. The rate of elimination is proportional to the plasma concentration

E. the metabolic ability has reached saturation.

2. Of the following, which will be blocked

by atropine and scopolamine? A. bradycardia

B. salivary secretion C. bronchoconstriction 13

D. skeletal muscle contraction E. miosis

3. The agents which can be used to treat glaucoma have A. timolol B. pindolol

C. physostigmine D. acetazolamide E. pilocarpine 4. A 34yearold

woman with schizophrenia has been treated for several years with various

drugs. She is now being treated with fluphenazine and complains of amenorrhea(闭经) and galactorrhea（溢乳）. Which of the following drugs would be appropriate to switch her medication to A. haloperidol

B. risperidone (利培酮) C. olanzapine (奥氮平) D. clozapine E. thioridazine

5. Which of the following drugs may cause dependence? A. methadone B. naloxone C. ibuprofen D. buspirone E. diazepam

6. Which of the following drugs can be used in treatment of depressive disorder? A. imipramine B. fluoxetine C. perphenazine D. selegiline E. paroxetine

7. The agents which are effective in the treatment of Parkinson’s disease are A. pirenzepine B. amantadine C. anisodamine D. levodopa E. scopolamine

8. Which of the following statements about the treatment of chronic heart failure are right?

A. Patients with evidence of fluid retention should receive a diuretic.

B. Treatment with an ACE inhibitor and a βR

blocker should be initiated and maintained unless specifically contraindicated. C. Digoxin may be added if needed to

reduce symptoms or to slow the ventricular repsonse 14

in patients with rapid atrial fibrillation. D. Patients with severe heart failure should also receive a βR blocker

E. Spironolactone may reduce mortality in patients with severe heart failure 9. Precautions advisable when using lovastatin include

A. serum transaminase measurements B. renal function studies C. acoustic measurement

D. serum creatinine kinase measurements E. monthly complete blood counts 10. Precautions advisable when using amiodarone include

A. serum transaminase measurements B. renal function studies C. acoustic measurement

D. serum T3、T4 measurements E. Xray chest check

11. In a hypertensive patient who is taking insulin to treat diabetes, which of the following

drugs is to be used with extra caution and advice to the patient?

A. prazosin B. hydralazine C. propranolol D. captopril E. losartan

12. Drugs that can enhance the sensitivity of insulin include A. repaglinide B. rosiglitazone C. pioglitazone D. acarbose E. metformin

13. The antiinflammatory mechanisms of glucocorticoids (GCS) include

A. GCS combined with GRE ,induce synthesis of ACE

B. GCS combined with GRE ,induce synthesis of lipocortin1

C. GCS combined with nGRE ,inhibit the expression of ICAM1 and ELAM1

D. GCS promote the apoptosis of inflammatory cell

E. GCS combined with steroid receptor of cell membrane and mitochondrial membrane.

14. Which of the following statements about cimetidine are WRONG

A. increase the secreation of gastric acid B. block androgen receptor

C. enhance the immunologic function D. induce acne（痤疮） E. treat zolingerEllison

syndrom and countercurrent esophagitis 15

15. Which of the following megaloblastic amemia are NOT the indication of folic acid A. megaloblastic anemia caused by AIDS B. megaloblastic anemia caused by TMP C. megaloblastic anemia caused by MTX D. megaloblastic anemia caused by pyrimethamine(乙胺嘧啶)

E. megaloblastic anemia caused by malignant tumor

16. The drugs which can protect gastric mucosa and inhibit helicobacter pylori include

A. omeprazole B. sucralfate

C. colloidal bismuth subcitrate D. cimetidine E. pirenzepine

17. Quinolones can NOT be used to patients who

A. have epilepsy history

B. are in growth and development period C. are taking antiacid D. are pregnant

E. are allergic to penicillin

18．Besides their antibacterial activity, macrolides agents also

A．promote gastrointestinal motility

B．have strong immunosuppressive action C．be used to treat bronchial asthma D．expel parasite in intestinal tract E．have antitumor action

19．Of the following, the true statements about Rifampin are

A. it can produce resistance to mycobacterium tuberculosis when administered only

B. it is effective on chlamydia trachomatis C. it has no effect on Staphylococcus aureus D. it is inductor of liver drug enzyme E. it can interfere with RNA synthesis 20. The agents that can inhibit bacterial protein synthesis include A. clindamycin B. streptomycin C. amantadine D. isoniazide

E. azithromycin二、选择题

1.A 2.E 3.E 4.B 5.C 6.D 7.D 8.D 9.A 10.C 11.D 12.D 13.E

14.D 15.C 16.C 17.B 18.C 19.D 20.D 21.B 22.B 23.A 24.D 25.D 26.C 27.D

28.E 29.E 30.E 31.C 32.B 33.B 34.E 35.C 36.E 37.B 38.A 39.E

40.C 41.D 42.E 43.C 44.E 45.C 46.E 47.B 48.C 49.A 50.B 51.C

52.B 53.A 54.E 55.D 56.C 57.A 58.B 59.C 60.B 61.BD 62.ABCE

63.ACDE 64.BCD 65.AE 66.ABDE 67.BDE 68.ABCE 69.AD 70.ADE

71.CD 72.BC 73.ABCDE 74.AD 75.BCD 76.ABC 77.ABCD

78.ABCDE 79.ABDE 80ABE

山东大学医学院（2006 —— 2007 学年第二学期）

2004 级 临床医学七年制 药理学期末考试试题（A 卷）

一、选择题：（A 型每题 0.5 分，X 型每题 1 分, 共 50 分）

Type A Choice questions (only one answer is correct)

1．A drug with t1/2 3 hours is given intravenously, the steady state of plasma concentration

can be expected within A．3 hrs B．8 hrs C．10 hrs D．15 hrs E．20 hrs

2．Which of the following is true for a drug whose elimination from plasma shows first order kinetics?

A. the half life

of the drug is proportional to the drug concentration in plasma

B. the amount eliminated per unit time is constant

C. the rate of elimination is proportional to the plasma concentration

D. elimination involves a rate limiting enzyme reaction operating at its maximal velocity

E. a plot of drug concentration versus time is a straight line

3．A drug eliminated with first order kinetics, the concentration of the drug in

plasma is

200mg/L, at 10 o ’ clock in the morning after administration of a single dose, the drug plasma

concentration is 25 mg/L, at 10 o ’ clock on second day morning, its t1/2 is

A．4h B．6h C．12h D．24h E．8h

4. Aspirin is a weak acid with 4.5 of pKa, what percentage of lipidsoluble form will be in the

stomach juice with 2.5 of pH? A. 0.99% B. 9% C. 9.09% D. 90.9% E. 99.0%

5. In this graph，drugs A，B and C are analogs，then

A. A has a greater potency than B B. A has a greater efficacy than C C. B has less potency than C

D. A has a greater potency than C E. B has a greater efficacy than C

6. Which of the following statements is correct?

A. if 10mg of drug A produces the same response as 100mg of drug B, drug A is more

efficacious than drug B.

B. the greater the efficacy, the greater the potency of a drug

C. in selecting a drug, potency is usually more important than efficacy

D. a competitive antagonist increases ED50 E. variation in response to a drug among different individuals is most likely to occur with a

drug showing a large therapeutic index 7. Among the following drugs, which will be excreted most quickly in acidic urine？