缬沙坦联合酒石酸美托洛尔治疗原发性高血压并冠心病的效果评价 下载本文

缬沙坦联合酒石酸美托洛尔治疗原发性高血压并冠心病的

效果评价

【摘要】目的探?缬沙坦联合酒石酸美托洛尔治疗原发性高血压并冠心病的临床效果。方法 84例原发性高血压并冠心病患者,随机分为研究组和对照组,各42例。对照组使用硝苯地平缓释片口服治疗,研究组使用缬沙坦联合酒石酸美托洛尔治疗。比较两组患者治疗前后的血压水平、心绞痛症状改善情况和生活质量评分。结果治疗4周后,研究组的收缩压、舒张压分别为(131.61±11.30)、(75.63±9.24)mm Hg (1 mm Hg=0.133 kPa),均低于对照组的(147.27±13.45)、(87.14±9.61)mm Hg,差异均具有统计学意义(P 【关键词】缬沙坦;酒石酸美托洛尔;原发性高血压;冠心病

DOI:10.14163/j.cnki.11-5547/r.2016.33.005 Evaluation of effect by valsartan combined with metoprolol tartrate in the treatment of primary hypertension combined with coronary heart disease WU Yi-ming. Department of Internal Medicine, Guangzhou City Liwan District Hospital of Traditional Chinese Medicine, Guangzhou 510160, China

【Abstract】 Objective To investigate clinical effect by

valsartan combined with metoprolol tartrate in the treatment of primary hypertension combined with coronary heart disease. Methods A total of 84 patients of primary hypertension combined with coronary heart disease were randomly divided into research group and control group, with 42 cases in each group. The control group received oral administration of nifedipine sustained release tablets for treatment, and the research group received valsartan combined with metoprolol tartrate for treatment. Comparison was made on blood pressure levels, improvements of angor pectoris symptom and quality of life scores between the two groups before and after treatment. Results After 4 weeks of treatment, the research group had systolic pressure and diastolic pressure respectively as (131.61±11.30) and (75.63±9.24) mm Hg (1 mm Hg=0.133 kPa), which were all lower than (147.27±13.45) and (87.14±9.61) mm Hg in the control group, and their differences all had statistical significance (P 【Key words】 Valsartan; Metoprolol tartrate; Primary hypertension; Coronary heart disease

原发性高血压是临床常见的慢性疾病之一,为多因素综合作用的结果,病情严重者可并发冠心病,严重影响患者的生存质量[1]。平稳控制患者血压,积极缓解心绞痛症状,对

明显改善预后情况、降低病死率至关重要[2, 3]。为探讨缬沙坦联合酒石酸美托洛尔治疗原发性高血压并冠心病的临床效果,本研究选取本院84例原发性高血压并冠心病患者作为研究对象,研究缬沙坦联合酒石酸美托洛尔治疗原发性高血压并冠心病的效果。现报告如下。 1 资料与方法

1. 1 一般资料选取2014年3月~2016年3月本院收治的84例原发性高血压并冠心病患者为研究对象,患者均符合原发性高血压合并冠心病的诊断标准,同意参与本次研究。84例患者随机分为研究组和对照组,每组42例。研究组男23例,女19例;年龄42~74岁,平均年龄(54.56±7.35)岁;病程1~7年,平均病程(5.04±1.57)年;合并高血脂12例,高血糖6例。对照组男24例,女18例;年龄41~78岁,平均年龄(54.91±7.73)岁;病程1~8年,平均病程(5.28±1.63)年;合并高血脂13例,高血糖7例。两组患者性别、年龄等一般资料比较差异无统计学意义(P>0.05),具有可比性。

1. 2 方法对照组患者给予个体化饮食及针对性健康教育,给予硝苯地平缓释片(商品名:圣通平,广东环球制药有限公司,国药准字H44024160,规格:10 mg)口服, 20 mg/次, 2次/d,治疗4周。研究组给予缬沙坦胶囊(商品名:代文,北京诺华制药有限公司,国药准字H20040217,规格: