榫欐簮鏈熷垔缃?/p>
http://www.qikan.com.cn
ERK1/2
淇″彿閫氳矾涓庨鍏宠妭鐐庤蒋楠ㄧ粏鑳炴椿鎬?/p>
鍙婂叾娌荤枟鐨勭浉鍏虫�х爺绌?/p>
浣滆�咃細闄堟辰鍗?/p>
鏉庢
鏉ユ簮锛氥�婇婀跨梾涓庡叧鑺傜値銆?/p>
2015
骞寸
01
鏈?/p>
銆愭憳
瑕併�?/p>
缁嗚優澶栦俊鍙疯皟鑺傛縺閰?/p>
1/2
鏄笣瑁傚師娲诲寲铔嬬櫧婵�閰跺鏃忎腑鐨勪竴涓噸瑕佷簹鍨嬶紝鍙備笌
楠ㄥ叧鑺傜値鍙戠梾鐨勬暣涓繃绋嬶紝鍏舵満鍒朵笌缁嗚優澶栦俊鍙疯皟鑺傛縺閰?/p>
1/2
鍙�氳繃璋冭妭鍏宠妭杞缁嗚優鐨勫
娈栥�佸噵浜℃椿鎬ф湁鍏炽�傜爺绌剁粏鑳炲淇″彿璋冭妭婵�閰?/p>
1/2
涓庨鍏宠妭鐐庡彂鐥呮満鍒剁殑鍏崇郴锛屼负楠ㄥ叧鑺傜値鐨?/p>
涓村簥娌荤枟鎻愪緵鏂版柟娉曞拰鏂版�濊矾銆?/p>
銆愬叧閿瘝銆?/p>
楠ㄥ叧鑺傜値
;
杞缁嗚優
;
缁嗚優澶栦俊鍙疯皟鑺傛縺閰?/p>
;
淇″彿閫氳矾
;
缁艰堪
doi
锛?/p>
10.3969/j.issn.2095-4174.2015.01.016
楠ㄥ叧鑺傜値锛?/p>
osteoarthritis
锛?/p>
OA
锛夋槸涓村簥澶氬彂鐨勮�佸勾浠ｈ阿鎬ч鐥咃紝鍏剁梾鐞嗚〃鐜颁互鍏宠妭杞鎹?/p>
瀹充负涓伙紝甯哥疮鍙婃暣涓叧鑺傜粍缁囥�傚ぇ闄嗗湴鍖?/p>
40
宀佷互涓婁汉缇ゅ師鍙戞�?/p>
OA
鎮ｇ梾鐜?/p>
46.3%
锛屽叾涓敺鎬?/p>
涓?/p>
41.6%
锛屽コ鎬т负
50.4%
锛岄殢鐫�骞撮緞鐨勫澶ц�岄�愭笎鍗囬珮锛屾湰鐥呯殑鑷存畫鐜囬珮杈?/p>
53%[1]
銆?/p>
OA
鐨勫彂
鐥呮満鍒跺皻涓嶆槑纭紝鐜颁唬鍖诲娌荤枟杩滄湡鐤楁晥灏氫笉鑲畾锛屼腑鍖绘爣鏈吋娌伙紝鍚勬湁鐗硅壊锛岀洰鍓嶄腑瑗垮尰缁?/p>
鍚堜繚瀹堟不鐤椾粛涓轰复搴婂父鐢ㄦ不鐤楁柟娉?/p>
[2]
銆傝繎骞存潵锛屼俊鍙烽�氳矾鍦?/p>
OA
鍙戠梾鏈哄埗涓殑鐮旂┒鏇村姞娣卞叆锛?/p>
鍙戠幇缁嗚優澶栦俊鍙疯皟鑺傛縺閰讹紙
extracellular signal regulated kinase
锛?/p>
ERK
锛夐�氳矾鍦?/p>
OA
鐨勫彂鐥呬笌娌?/p>
鐤楄繃绋嬩腑鏈夊叧閿綔鐢紝鐜板皢鍏剁患
杩板涓嬨�?/p>
1 ERK
涓濊鍘熸椿鍖栬泲鐧芥縺閰讹紙
mitogen-activated protein kinase
锛?/p>
MAPK
锛夌骇鑱旈�斿緞鏄粏鑳炰俊鍙疯浆
瀵肩殑閲嶈閫斿緞锛屽畠鑳藉皢鍕熼泦鍒扮殑澶氱缁嗚優澶栦俊鍙凤紙濡傜敓闀垮洜瀛愩�佺粏鑳炲洜瀛愮瓑锛夌７閰稿寲娲诲寲鍚庨�?/p>
绾т紶閫掑埌缁嗚優鏍革紝骞舵縺娲诲绉嶆牳杞綍鍥犲瓙鍙備笌澶氱鐢熺悊杩囩▼
[3]
銆傝蒋楠ㄧ粏鑳炵殑鍑嬩骸銆佺値鐥囧弽
搴斻�佸熀璐ㄩ噾灞炶泲鐧介叾锛?/p>
matrix metalloproteinases
锛?/p>
MMPs
锛夌殑婵�娲荤瓑閮戒笌
MAPKs
淇″彿浼犲閫氳矾
鏈夊叧
[4]
銆?/p>
MAPKs
瀹舵棌鍖呮嫭
c-Jun N-
鏈婵�閰讹紙
c Jun N terminal kinases
锛?/p>
JNK
锛夈�?/p>
p38
婵�閰躲�?/p>
ERK
銆佸ぇ
MAPK
閫氳矾锛?/p>
BMK1/ERK5
锛夈�?/p>
ERK3
銆?/p>
ERK27
銆?/p>
NLK
鍜?/p>
ERK8
绛?/p>
8
涓簹瀹舵棌銆?/p>
ERK
鏄劘姘ㄩ吀瀵煎悜鐨勪笣姘ㄩ吀銆佽嫃姘ㄩ吀婵�閰讹紝
1991
骞?/p>
Sturgill
绛夊湪鍝轰钩鍔ㄧ墿缁嗚優閴村畾鍑猴紝瀹冨箍娉涘瓨鍦?/p>
浜庡摵涔冲姩鐗╃粏鑳炰腑
[5]
銆?/p>
ERK
鍖呮嫭涓や釜鍚屾簮鎬ч珮杈?/p>
90%
鐨勪簹鍨嬶細
ERK1
鍜?/p>
ERK2
锛?/p>
Ras
鍜?/p>
ERK
鐩?/p>
浜掍箣闂存瀯鎴愪簡涓�鏉″畬鏁?/p>
Ras/Raf/MEK/ERK
淇″彿閫氳矾锛屽苟渚濇椤哄簭婵�娲诲彲鍙備笌缁嗚優澧炴畺鍜屽噵浜?/p>
绛変俊鍙蜂紶瀵?/p>
[6]
銆傚湪
MAPKs
瀹舵棌涓紝鐩墠宸茶瘉瀹烇紝鍙備笌
OA
鍙戠梾鐨勬湁
JNK
銆?/p>
p38
婵�閰跺強
ERK[7]
锛屽叾涓?/p>
ERK1/2
淇″彿杞閫氳矾鏄彈澶栫晫鍒烘縺鏃跺喅瀹氱粏鑳炲懡杩愮殑鍏抽敭鍥犵礌锛屽畠涓昏鏄績杩?