绗竴绔?/p>
鎬昏
涓�銆佽娑茬郴缁熺殑缁勬垚
琛�娑茬郴缁燂細琛�娑插拰閫犺鍣ㄥ畼缁勬垚锛?/p>
琛�娑诧細琛�娴嗗拰琛�缁嗚優锛堢孩缁嗚優銆佺櫧缁嗚優銆佽灏忔澘锛夌粍鎴愶紱
閫犺鍣ㄥ畼锛氶楂撱�佽兏鑵恒�佽劸鑴忋�佹穻宸寸粨銆?/p>
浜屻�侀�犺骞茬粏鑳炲拰閫犺
锛堜簩锛夐�犺骞茬粏鑳烇紙
hematopoietic stem cell,HSC
锛?/p>
1
銆佸畾涔夛細
HSC
鏉ユ簮浜庤儦鑳庡嵉榛勫泭涓儦灞傜粏鑳烇紝鏄竴绉嶇粍缁囩壒寮傛�у共缁嗚優锛屽叿鏈?/p>
鑷垜澶嶅埗鍜屽鍚戝垎鍖栨綔鑳斤紝鍙娈栧垎鍖栦负娣嬪反缁嗚優鍙婂悇绫婚�犺缁嗚優骞剁淮鎸佹満浣撻�犺
鍔熻兘銆?/p>
2
銆侀�犺骞茬粏鑳炵壒鐐?/p>
锛?/p>
1
锛?/p>
澧炴畺鐗圭偣锛?/p>
鑷垜澶嶅埗涓庡鍚戝垎鍖栫殑鍔ㄦ�佸钩琛★紱
鍙兘涓?/p>
HSC
鐨勪笉瀵圭О鍒嗚鎴栫粏
鑳炲洜瀛愯皟鑺傛湁鍏筹紝
浣?/p>
HSC
鍒嗚鏃跺嵆淇濇寔鑷垜澶嶅埗鐗规�у悓鏃跺叿澶囩浉瀵规垚鐔熸�э紝
鑳藉悜鍚?/p>
绯诲垎鍖栵紝淇濇寔浜?/p>
HSC
姹犵殑鏁伴噺鍜岀壒鎬х殑绋冲畾骞惰兘鍒嗗寲涓哄悇绉嶈缁嗚優銆?/p>
锛?/p>
2
锛夐�犺骞茬粏鑳炵殑缁勬垚锛?/p>
澶氳兘閫犺骞茬粏鑳?/p>
锛?/p>
pluripotent hematopoietic stem cell,PHSC
锛?/p>
锛?/p>
鏄渶鏃╂湡鐨勯�犺骞?/p>
缁嗚優锛?/p>
鑳界淮鎸佹満浣撻暱鏈熼�犺鍔熻兘锛?/p>
鍏惰嚜鎴戞洿鏂板強澶氬悜鍒嗗寲淇濇寔鍔ㄦ�佸钩琛★紝
鏁伴噺绋冲畾銆?/p>
鏃㈠線绉颁负鑴鹃泦钀藉舰鎴愬崟浣嶏紙
colony-forming unit-spleen,CFU-S
锛?/p>
銆?/p>
瀹氬悜閫犺骞茬粏鑳烇紙
committed hematopoietic stem cell
锛?/p>
锛氬鑳介�犺骞茬粏鑳炶繘鍏ュ垎鍖?/p>
澧炴畺锛屽彲鍒嗗寲涓洪珦绯婚�犺骞茬粏鑳炲拰娣嬪反绯婚�犺骞茬粏鑳烇紝绉颁负瀹氬悜閫犺骞茬粏鑳炪�?/p>
锛堜笁锛夐�犺寰幆澧?/p>
1
銆?/p>
瀹?/p>
涔?/p>
锛?/p>
閫?/p>
琛�
寰?/p>
鐜?/p>
澧?/p>
浜?/p>
绉?/p>
閫?/p>
琛�
璇?/p>
瀵?/p>
寰?/p>
鐜?/p>
澧?/p>
锛?/p>
hematopoietic
inductive
microenvironment
锛?/p>
HIM
锛?/p>
锛屾槸灞�闄愰�犺鍣ㄥ畼鎴栫粍缁囧唴锛屽叿鏈夌壒寮傛�х殑缁撴瀯鍙婄敓鐞嗗姛
鑳界殑鐜锛岀敱閫犺鍣ㄥ畼涓殑鍩鸿川缁嗚優銆佸熀璐ㄧ粏鑳炲垎娉岀殑缁嗚優澶栧熀璐ㄥ拰鍚勭閫犺璋冭妭