鑽悊瀛︿綔涓氱瓟妗?/p>
绗竴绔?/p>
缁█
浣滀笟涓�锛氳瘯杩拌嵂鐞嗗鐨勭爺绌舵柟娉曟湁鍝簺锛?/p>
绛旓細瀹為獙鑽悊瀛︽柟娉曟槸浠ュ姩鐗╀负鐮旂┒瀵硅薄锛岀爺绌惰嵂鐗╀笌鍔ㄧ墿涔嬮棿鐩镐簰浣滅敤鐨勮寰嬨�傚寘
鎷暣浣撳疄楠屻�佹椿浣撹В鍓栧拰绂讳綋瀹為獙鎴栬瘯绠″疄楠岋紱瀹為獙娌荤枟瀛︽柟娉曟槸棰勫厛閲囩敤瀹為獙鐥呯悊瀛︽柟
娉曞鍔ㄧ墿閫犳垚鐤剧梾鐥呯悊妯″瀷锛屼互瑙傚療鑽墿鐨勬不鐤椾綔鐢紱涓村簥鑽悊瀛︽柟娉曟槸鍦ㄤ汉浣撲笂杩涜瑙?/p>
瀵燂紝闃愭槑鑽墿鐨勪复搴婄枟鏁堛�佷笉鑹弽搴斻�佹彁鍐呰繃绋嬶紝瀵硅嵂鐗╀綔鍑烘渶鍚庣殑涓村簥璇勪环銆?/p>
绗簩绔?/p>
鑽墿鏁堝簲鍔ㄥ姏瀛?/p>
浣滀笟涓�锛氳瘯杩拌嵂鐗╀綔鐢ㄤ笌鑽悊鏁堝簲鐨勫尯鍒�?/p>
绛旓細鑽墿浣滅敤锛?/p>
drug
action
锛夋槸鎸囪嵂鐗╁鏈轰綋缁嗚優鐨勯棿鐨勫垵濮嬩綔鐢紝鏄姩鍥狅紝鏄垎瀛?/p>
鍙嶅簲鏈哄埗銆傝嵂鐞嗘晥搴?/p>
(pharmacological
effect)
鏄満浣撳櫒瀹樺師鏈夊姛鑳芥按骞崇殑鏀瑰彉锛屾槸鑽墿
浣滅敤鐨勭粨鏋溿�傚姛鑳芥彁楂樼О鍏村锛?/p>
exicitation
锛?/p>
锛涘姛鑳介檷浣庢垚涓烘姂鍒?/p>
(inhibition)
銆侀夯鐥?/p>
(paralysis)
銆?/p>
绗笁绔?/p>
鑽墿浠ｈ阿鍔ㄥ姏瀛?/p>
浣滀笟涓�锛氳瘯杩拌嵂鍔ㄥ鍙傛暟鐨勬蹇靛強鑽悊瀛︽剰涔夈�?/p>
绛旓細鍗婅“鏈燂紙
t1/2
锛?/p>
:
琛�娴嗚嵂鐗╂祿搴﹂檷浣庝竴鍗婃墍闇�鏃堕棿绉板崐琛版湡锛?/p>
t1/2
锛?/p>
锛涙秷闄ら�熺巼甯?/p>
鏁?/p>
锛?/p>
K
锛?/p>
:
鍗曚綅鏃堕棿鍐呰嵂鐗╂秷闄ょ殑鐧惧垎閫熺巼绉版秷闄ら�熺巼甯告暟銆?/p>
鍗婅“鏈熶笌娑堥櫎閫熺巼甯告暟涔嬮棿鐨?/p>
鍏崇郴鍙敤
t1/2=0.693/K
鏉ヨ〃绀猴紱鐢熺墿鍒╃敤搴?/p>
(bioavilability
锛?/p>
)
:
F=AUC((op))/AUC(iv)
x100%
锛涙竻闄ょ巼锛?/p>
clearanse,CL
锛?/p>
: CL=K.Vd
锛涘垎甯冨绉紙
Vd
锛?/p>
:
绛変簬浣撳唴鎬昏嵂閲忎笌琛�鑽祿
搴︾殑姣斿�硷紝鍗?/p>
Vd=A
锛?/p>
mg
锛?/p>
/ C
锛?/p>
mg/L
锛?/p>
锛屽崟浣嶄负鍗囷紙
L
锛?/p>
銆傚畠涓嶆槸涓�涓湡瀹炵殑浣撶Н锛?/p>
鍙兘杩?/p>
浼肩殑璇存槑鑽墿鍦ㄤ綋鍐呭垎甯冪殑骞跨嫮绋嬪害銆?/p>
鍒嗗竷瀹圭Н澶х殑鑽墿
,
缁勭粐鍒嗗竷骞匡紝
鍙嶄箣鍒欑粍缁囧垎甯冨皯銆?/p>
绗洓绔?/p>
浼犲嚭绁炵粡绯荤粺鑽悊瀛︽璁?/p>
浣滀笟涓�锛氳瘯杩颁紶鍑虹缁忕郴缁熺殑鍙椾綋鍒嗗瀷銆?/p>
绛旓細
鑳戒笌
Ach
缁撳悎鐨勫彈浣撶О涓轰箼閰拌儐纰卞彈浣撱�?/p>
鍙垎涓烘瘨钑堢⒈鍨嬭儐纰卞彈浣?/p>
锛?/p>
M
鑳嗙⒈鍙椾綋锛?/p>
鍜岀儫纰卞瀷鑳嗙⒈鍙椾綋锛?/p>
N
鑳嗙⒈鍙椾綋锛?/p>
銆傚彲涓?/p>
NA
銆?/p>
AD
缁撳悎鐨勫彈浣撶О鑲句笂鑵虹礌鍙椾綋锛屽彲鍒嗕负
伪
鑲?/p>
涓婅吅绱犲彈浣擄紙
伪
鍙椾綋锛夊拰
尾
鑲句笂鑵虹礌鍙椾綋锛?/p>
尾
鍙椾綋锛?/p>
銆?/p>
M
鑳嗙⒈鍙椾綋鍒嗕簲绉嶄簹鍨嬶紝鍗?/p>
M1
銆?/p>
M2
銆?/p>
M3
銆?/p>
M4
銆?/p>
M5
锛?/p>
N
鑳嗙⒈鍙椾綋鍒嗕袱绉嶄簹鍨嬶紝鍗?/p>
Nm
鍙椾綋銆?/p>
Nn
鍙椾綋銆?/p>
伪
鍙椾綋鍒嗕负
伪
1
銆?/p>
伪
2
涓ょ浜?