鑽墿浠ｈ阿鍔ㄥ姏瀛?/p>
锛?/p>
pharmacokinetics
锛夌畝绉拌嵂浠ｅ姩瀛︽垨鑽姩瀛︼紝涓昏鏄畾閲?/p>
鐮旂┒鑽墿鍦ㄧ敓鐗╀綋鍐呯殑杩囩▼锛堝惛鏀躲�佸垎甯冦�佷唬璋㈠拰鎺掓硠锛夛紝骞惰繍鐢ㄦ暟瀛﹀師鐞嗗拰鏂?/p>
娉曢槓杩拌嵂鐗╁湪鏈轰綋鍐呯殑鍔ㄦ�佽寰嬬殑涓�闂ㄥ绉戙�?/p>
纭畾鑽墿鐨勭粰鑽墏閲忓拰闂撮殧鏃堕棿鐨?/p>
渚濇嵁锛?/p>
鏄鑽湪瀹冪殑浣滅敤閮ㄤ綅鑳藉惁杈惧埌瀹夊叏鏈夋晥鐨勬祿搴︺�?/p>
鑽墿鍦ㄤ綔鐢ㄩ儴浣嶇殑娴撳害
鍙楄嵂鐗╀綋鍐呰繃绋嬬殑褰卞搷鑰屽姩鎬佸彉鍖栥�?/p>
鍦ㄥ垱鏂拌嵂鐗╃爺鍒惰繃绋嬩腑锛?/p>
鑽墿浠ｈ阿鍔ㄥ姏瀛︾爺
绌朵笌鑽晥瀛︾爺绌躲�?/p>
姣掔悊瀛︾爺绌跺浜庡悓绛夐噸瑕佺殑鍦颁綅锛?/p>
宸叉垚涓鸿嵂鐗╀复搴婂墠鐮旂┒鍜屼复
搴婄爺绌剁殑閲嶈缁勬垚閮ㄥ垎銆?/p>
鍖呮嫭鑽墿娑堥櫎鍔ㄥ姏瀛︼細
涓�绾ф秷闄ゅ姩鍔涘
锛堝崟浣嶆椂闂村唴娑?/p>
闄ょ殑鑽噺涓庤娴嗚嵂鐗╂祿搴︽垚姝ｆ瘮锛?/p>
鍙堝彨鎭掓瘮娑堥櫎锛?/p>
鍜岄浂绾ф秷闄ゅ姩鍔涘
锛堝崟浣嶆椂闂?/p>
鍐呬綋鍐呰嵂鐗╂寜鐓ф亽瀹氱殑閲忔秷闄わ紝鍙堝彨鎭掗噺娑堥櫎锛?/p>
鑽墿浠ｈ阿鍔ㄥ姏瀛︾殑閲嶈鍙傛暟锛?/p>
1
銆佽嵂鐗╂竻闄ゅ崐琛版湡锛?/p>
half
life
锛?/p>
t
1/2
锛夛紝鏄娴嗚嵂鐗╂祿搴︿笅闄嶄竴鍗婃墍闇�瑕?/p>
鐨勬椂闂淬�傚叾闀跨煭鍙弽鏄犱綋鍐呰嵂鐗╂秷闄ら�熷害銆?/p>
2
銆佹竻闄ょ巼锛?/p>
clearance
锛?/p>
CL
锛夛紝鏄満浣撴竻闄ゅ櫒瀹樺湪鍗曚綅鏃堕棿鍐呮竻闄よ嵂鐗╃殑琛�
娴嗗绉紝鍗冲崟浣嶆椂闂村唴鏈夊灏戜綋绉殑琛�娴嗕腑鎵�鍚嵂鐗╄鏈轰綋娓呴櫎銆備娇浣撳唴鑲濊剰銆?/p>
鑲捐剰鍜屽叾浠栨墍鏈夋秷闄ゅ櫒瀹樻竻闄よ嵂鐗╃殑鎬诲拰銆?/p>
3
銆佽〃瑙傚垎甯冨绉紙
apparent volume of distribution
锛?/p>
V
d
锛夛紝鏄寚褰撹娴?/p>
鍜岀粍缁囧唴鑽墿鍒嗗竷杈惧埌骞宠 鍚庯紝
浣撳唴鑽墿鎸夋鏃剁殑琛�娴嗚嵂鐗╂祿搴﹀湪浣撳唴鍒嗗竷鏃舵墍
闇�鐨勪綋娑插绉�?/p>
4
銆佺敓鐗╁埄鐢ㄥ害锛?/p>
bioavailability
锛?/p>
F
锛夛紝鍗宠嵂鐗╃粡琛�绠″閫斿緞缁欒嵂鍚庡惛鏀?/p>
杩涘叆鍏ㄨ韩琛�娑插惊鐜嵂鐗╃殑鐩稿閲忋�傚彲鍒嗕负缁濆鐢熺墿鍒╃敤搴﹀拰鐩稿鐢熺墿鍒╃敤搴︺�?/p>
浣撳唴杩囩▼
鍗宠嵂鐗╄鍚告敹杩涘叆鏈轰綋鍒版渶鍚庤鏈轰綋鎺掑嚭鐨勫叏閮ㄥ巻绋嬶紝鍖呮嫭鍚告敹銆佸垎甯冦�佷唬
璋㈠拰鎺掓硠绛夎繃绋嬨�?/p>
鍏朵腑鍚告敹銆?/p>
鍒嗗竷鍜屾帓娉勫睘鐗╃悊鍙樺寲绉颁负杞繍銆?/p>
浠ｈ阿灞炰簬鍖栧鍙?/p>
鍖栦害绉拌浆鍖栥�傛満浣撳鑽墿浣滅敤鐨勮繃绋嬶紝琛ㄧ幇涓轰綋鍐呰嵂鐗╂祿搴﹂殢鏃堕棿鍙樺寲鐨勮寰嬨�?/p>
鑽墿鍔ㄥ姏瀛︽槸鐮旂┒鑽墿浣撳唴杩囩▼瑙勫緥锛岀壒鍒槸鐮旂┒琛�鑽祿搴﹂殢鏃堕棿鑰屽彉鍖栫殑瑙?/p>
寰嬨�?/p>
1.
鍚告敹锛?/p>
absorption
锛?/p>
鑽墿浠庣粰鑽儴浣嶈繘鍏ヨ娑插惊鐜殑杩囩▼绉颁负鍚告敹銆傚奖鍝嶅惛鏀剁殑鍥犵礌涓昏鏈夛細
1
銆佺粰鑽�斿緞锛氬惛鏀堕�熷害锛氬惛鍏?/p>
>
鑸屼笅
>
鑲屾敞
>
鐨笅
>
鐩磋偁
>
鍙ｆ湇
>
鐨偆銆?/p>
2
銆佽嵂鐗╂�ц川锛?/p>
锛?/p>
1
锛夎剛婧舵�э細鑴傛憾鎬ц秺澶э紝鍚告敹瓒婂揩锛?/p>
锛?/p>
2
锛夋按婧舵�э細鏄撴憾浜庢按鐨勮嵂鐗╂槗鍚告敹锛?/p>
锛?/p>
3
锛夌瑙ｅ害锛氫笉瑙ｇ閮ㄥ垎鑴傛憾鎬ц緝澶э紝鏄撳惛鏀讹紱鑰岃В绂婚儴鍒嗭紝鐢变簬甯︽湁鏋?/p>
鎬э紝鑴傛憾鎬т綆锛岄毦浠ュ惛鏀躲�傘�?/p>
鍙ｆ湇鑽墿琚惛鏀惰繘鍏ヤ綋寰幆鐨勬瘮鐜囷紝
鍗崇粰鑽噺涓庡惛鏀堕噺鐨勬瘮鐜囩О涓虹敓鐗╁埄鐢?/p>
搴︼紙鎴栫敓鐗╁彲鐢ㄥ害锛夈�?/p>
2.
鍒嗗竷锛?/p>
distribution
锛?/p>
鑽墿鍚告敹鍚庝粠琛�娑插惊鐜埌杈炬満浣撳悇涓櫒瀹樺拰缁勭粐鐨勮繃绋嬬О涓哄垎甯冦�?/p>
褰卞搷鑽墿鍒嗗竷鐨勪富瑕佸洜绱犳湁锛?/p>
1
銆佽嵂鐗╃殑鎬ц川锛氳剛婧舵�уぇ鍒嗗竷鍒扮粍缁囧櫒瀹樼殑閫熷害蹇�?/p>
2
銆佽嵂鐗╀笌缁勭粐鐨勪翰鍜屽姏锛氭湁浜涜嵂鐗╁鏌愪簺缁勭粐鍣ㄥ畼鏈夌壒娈婄殑浜插拰鍔涖�傝嵂鐗?/p>
瀵圭粍缁囧櫒瀹樼殑浜插拰鍔涗笌鐤楁晥鍙婁笉鑹弽搴旀湁鍏炽�?/p>