Hippo
淇″彿閫氳矾绠�浠?/p>
鍚嶅瓧鐨勭敱鏉ワ細
鍏跺叧閿粍鎴愭垚鍛樿泲鐧芥縺閰?/p>
Hippo
绐佸彉鑳戒娇缁勭粐澧炵敓锛?/p>
鍦ㄦ灉铦囦腑鐨勮〃鍨嬬湅涓婂幓寰?/p>
鍍忔渤椹�?/p>
The Hippo signaling pathway, also known as the
Salvador/Warts/Hippo (SWH)
pathway
銆?/p>
銆?/p>
1
銆戜富瑕佸姛鑳?/p>
鍙備笌缁嗚優鐨勫娈栧強绋嬪簭鎬ф浜＄殑璋冩帶銆傚弬涓庣檶鐥囩殑褰㈡垚銆?/p>
1.Yki/YAP/TAZ
鏄師鐧屽熀鍥犮�?/p>
YAP
杩囪〃杈惧彲浠ヨВ闄ょ粏鑳炵殑鎺ヨЕ鎶戝埗
(contact inhibition)
銆?/p>
澶氱鐧岀棁涓彲浠ュ彂鐜?/p>
Hippo signaling
鐨勫熀鍥犵獊鍙橈紙濡?/p>
涔宠吅鐧屼腑鍙彂鐜?/p>
Fat4
绐佸彉锛夆�︹�?/p>
2.
璋冩帶鐢熺墿浣撳櫒瀹樼殑澶у皬銆?/p>
(
鍣ㄥ畼鍐嶇敓
)
鍦ㄥ皬榧犺倽鑴忚繃琛ㄨ揪
Yap
锛屽彂鐜板叾鍥犱负缁嗚優澧炵敓锛屽ぇ灏忔墿澶т簡
3
鍊嶅乏鍙炽�傚仠姝㈣繃琛ㄨ揪
Yap
锛?/p>
鑲濊剰鑳芥仮澶嶆甯稿ぇ灏忋�?/p>
陇
-
灏嗙粏鑳炶啘涓婄殑淇″彿
(
缁嗚優涓庣粏鑳炶创杩戠殑绋嬪害绛?/p>
)
浼犻�掑埌缁嗚優鏍镐腑銆傚拰缁嗚優鏋佹�у強缁嗚優楠ㄦ灦
鐩稿叧銆?/p>
銆?/p>
2
銆戜俊鍙烽�氳矾鐨勬垚鍛?/p>
Fat(FAT1-4 - mammals)
鈽?/p>
鍔熻兘锛?/p>
receptor [ps
閰嶄綋鏈煡
]
绫诲埆锛氳法鑶滆泲鐧斤紝
atypical cadherin
Dachsous (Ds)
鈽?/p>
鍔熻兘锛氭湭鐭?/p>
绫诲埆锛氳法鑶滆泲鐧斤紝
atypical cadherin
Crumbs (Crb)
G. Halder and RL. Johnson, 2011