榫欐簮鏈熷垔缃?/p>
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绯栧翱鐥呰偩鐥呭彂鐥呮満鍒剁爺绌惰繘灞?/p>
浣滆�咃細鑻?/p>
姣?/p>
鏉ユ簮锛氥�婁腑鍥藉疄鐢ㄥ尰鑽�?/p>
2009
骞寸
05
鏈?/p>
銆愬叧閿瘝銆?/p>
绯栧翱鐥呰偩鐥咃紱鍙戠梾鏈哄埗
绯栧翱鐥呰偩鐥?/p>
(DN)
鏄互绯昏啘缁嗚優澧炵敓鍜岀粏鑳炲鍩鸿川澧炲銆佽偩灏忕悆鍩哄簳鑶滃鍘氫笌鑲惧皬鐞冪‖鍖栦负
鍩烘湰鐥呯悊鐗瑰緛鐨勭梾鍙橈紝鍙戠敓鏈哄埗澶嶆潅锛岀洰鍓嶆湭瀹屽叏闃愭槑锛屽寘鎷偩灏忕悆琛�娑插姩鍔涘鏀瑰彉銆佺敓鍖栦唬
璋㈢磰涔便�佽娑叉祦鍙樺鍙樺寲銆佹哀鍖栧簲婵�銆佺粏鑳炲洜瀛愪笌閬椾紶鏄撴劅鎬х瓑澶氬洜绱犵浉浜掍綔鐢ㄥ鑷?/p>
DN
鐨勫彂
鐢熴�傜幇缁撳悎鍥藉唴澶栬祫鏂欙紝灏辫繎骞存潵瀵圭硸灏跨梾鑲剧梾
(DN)
鐨勫彂鐥呮満鍒剁爺绌剁患杩板涓嬨�?/p>
1
绯栧翱鐥呰偩鐥呭彂鐥呯値鐥囨満鍒剁爺绌惰繘灞?/p>
杩戝勾鏉ヤ复搴婁笌瀹為獙鐮旂┒琛ㄦ槑鍗充娇涓ユ牸鎺у埗琛�绯栥�佸簲鐢ㄨ绠＄揣寮犵礌杞崲閰舵姂鍒跺墏鎴栬绠＄揣寮?/p>
绱?/p>
II
鍙椾綋鎷姉鍓傞樆鏂偩绱?/p>
-
琛�绠＄揣寮犵礌绯荤粺
(Renin-angiotensin system
锛?/p>
RAS)
浠呭閮ㄥ垎
DN
鏈変竴
瀹氱殑寤剁紦浣滅敤锛屾櫄杩戠爺绌舵彮绀?/p>
DN
鐨勫彂鐥呭湪浠ｈ阿绱婁贡涓庤娴佸姩鍔涘鏈哄埗鍩虹涓婏紝鐐庢�у弽搴旀満鍒?/p>
鏄叾鎸佺画鍙戝睍鐨勫叧閿洜绱犮�傝偩鑴忓浐鏈夌粏鑳炲湪鐥呯悊鐘舵�佷笅鍙互浜х敓
TNF-
伪
銆?/p>
IL-1
銆?/p>
IL-6
銆?/p>
NO
绛?/p>
澶氱鐐庢�у弽搴斿洜瀛愶紝杩欎簺鍥犲瓙鍙堥�氳繃鑷垎娉屽拰鏃佸垎娉岀殑鏂瑰紡浣跨値鎬у弽搴旀晥搴斾笉鏂墿澶э紝寮曡捣鐐?/p>
鐥囩骇鑱斿弽搴斻�傛渶杩?/p>
Katherine
[1]
鎻愬嚭鎶婄硸灏跨梾鑲剧梾鐪嬩綔涓�绉嶇敱浠ｈ阿绱婁贡寮曡捣鐨勭値鎬у弽搴旀�х柧鐥呫�?/p>
1.1
楂樿绯栦笌绯栧翱鐥呰偩鐥呯値鎬у弽搴旂殑鍏崇郴
楂樿绯栨槸绯栧翱鐥呭熀鏈殑涓村簥琛ㄧ幇锛屼篃鏄弬涓庣硸灏?/p>
鐥呰偩鐥呭彂鐥呯殑涓昏浠ｈ阿绱婁贡銆備綋澶栬瘯楠岃瘉瀹烇紝绯栧埡婵�浜虹郴鑶滅粏鑳炲崟鏍哥粏鑳炶秼鍖栬泲鐧?/p>
(MCP-1)
鐨?/p>
琛ㄨ揪
[2]
銆傛彁绀猴細浣撳唴琛�绯栫幆澧冧笅锛岃偩灏忕悆绯昏啘缁嗚優琛ㄨ揪
MCP-1
澧炲姞锛屽紩璧峰法鍣粏鑳炵殑绉仛鍜?/p>
娲诲寲锛岄噴鏀惧悇绉嶇値鎬т粙鍜岀敓闀垮洜瀛愶紝淇冭繘缁嗚優澶栧熀璐?/p>
(ECM)
澧炲锛屽姞閫熻偩灏忕悆纭寲銆傚彟澶栵紝琛�
绯栦績杩涢珮绾х硸鍩哄寲缁堟湯浜х墿
(AGEs)
褰㈡垚锛?/p>
AGEs
鍜岃兌鍘熷垎瀛愮粨鍚堣兘鐩存帴鏀瑰彉琛�绠＄粨鏋勶紝寮曡捣琛�
绠″澧炲帤銆佺鑵旂嫮绐勶紱
AGEs
鍜岃繕鑳戒笌鑲惧皬鐞冪郴鑶滅粏鑳炶〃闈?/p>
AGEs
鍙椾綋缁撳悎锛屽埡婵�绯昏啘缁嗚優鍚?/p>
鎴愬ぇ閲忚灏忔澘琛嶅寲鐢熼暱鍥犲瓙
(PDGF)
銆佺粏鑳炲鍩鸿川鍜?/p>
MCP-1
锛屼骇鐢熻偩鑴忔參鎬х値鎬у弽搴斿拰绾ょ淮
鍖栥�傞珮琛�绯栥�?/p>
AGEs
銆佽泲鐧藉翱鍙互鍗忓悓鍒烘縺鑲捐剰瓒崇粏鑳炲拰鑲惧皬绠＄粏鑳炰骇鐢熻秼鍖栧洜瀛愶紝鍕熼泦宸ㄥ櫖
缁嗚優銆傛參鎬х値鐥囬�氳繃澶氱閫斿緞瀵艰嚧鑲捐剰鎹熶激锛?/p>
IL-6
銆?/p>
TNF-
伪
銆佸埡婵�琛�绠℃椿鎬х墿璐ㄩ噴鏀撅紝浣胯偩灏?/p>
鐞冪郴鑶滅粏鑳炲鐢燂紝鍐呯毊缁嗚優閫氶�忔�у鍔狅紱鐐庢�у弽搴斿彲寮曞彂鏈轰綋鐨勬哀鍖栧簲婵�锛屼娇
LDL(
浣庡瘑搴﹁剛
铔嬬櫧
)
姘у寲涓?/p>
ox LDL
锛屽悗鑰呭彲浠ョ洿鎺ユ崯浼よ偩灏忕悆鍐呯毊缁嗚優锛屽鍔犲崟鏍哥粏鑳炲琛�绠″唴鐨殑绮橀檮鍜?/p>
娴告鼎锛涙哀鍖栧簲婵�杩樺彲浠ヤ骇鐢熸椿鎬ф哀绨?/p>
(ROS)
锛岃瀵肩値鎬у弽搴斾粙璐ㄥ拰鐢熼暱鍥犲瓙鐨勭敓鎴愶紝浣跨粏鑳炲