榫欐簮鏈熷垔缃?/p>
http://www.qikan.com.cn
瑗块厼鏅叞涓庢枃鎷夋硶杈涙不鐤楁姂閮佺棁瀵圭収鐮旂┒
浣滆�咃細閭撴槬姹?/p>
楂樻案鑳?/p>
浜庡僵闇?/p>
寮犲悓鍏?/p>
鏉ユ簮锛氥�婁腑鍥藉疄鐢ㄥ尰鑽�?/p>
2011
骞寸
35
鏈?/p>
銆愭憳瑕併�?/p>
鐩殑
姣旇緝瑗块厼鏅叞涓庢枃鎷夋硶杈涙不鐤楁姂閮佺棁鐨勭枟鏁堝強瀹夊叏鎬с�傛柟娉?/p>
灏?/p>
60
渚嬫姂閮?/p>
鐥囨偅鑰呴殢鏈哄垎涓轰袱缁勶紝鍒嗗埆缁欎簣瑗块厼鏅叞涓庢枃鎷夋硶杈涙不鐤楋紝鐤楃▼
8
鍛ㄣ�傜敤姹夊瘑灏旈】鎶戦儊閲忚〃
(HAMD)
鍙婃眽瀵嗗皵椤跨劍铏戦噺琛?/p>
(HAMA)
鍦ㄦ不鐤楀墠鍙婃不鐤?/p>
2
銆?/p>
4
銆?/p>
6
銆?/p>
8
鍛ㄨ瘎瀹氱枟鏁堬紱鐢ㄥ壇鍙嶅簲閲忚〃
(TESS)
璇勫畾涓嶈壇鍙嶅簲銆傜粨鏋?/p>
涓ょ粍鎬讳綋鐤楁晥鐩稿綋锛岃タ閰炴櫘鍏拌捣鏁堢◢蹇�備袱缁勪笉鑹弽搴斿潎杈冭交锛?/p>
瀹夊叏鎬уソ銆傜粨璁?/p>
瑗块厼鏅叞涓庢枃鎷夋硶杈涘潎鏄畨鍏ㄦ湁鏁堢殑鎶楁姂閮佽嵂銆?/p>
銆愬叧閿瘝銆?/p>
瑗块厼鏅叞锛涙枃鎷夋硶杈涳紱鎶戦儊鐥?/p>
鎶戦儊鐥?/p>
(depression)
鏄竴绉嶄互鎯呯华浣庤惤涓轰富瑕佺壒寰佺殑绮剧鐤剧梾锛屽叾鐥呭洜鍜屽彂鐥呮満鍒跺皻涓嶆竻
妤氥�備负鎺㈣瑗块厼鏅叞涓庢枃鎷夋硶杈涘鎶戦儊鐥囩殑鐤楁晥鍜屽叾瀹夊叏鎬э紝鎴戜滑灏嗕袱鑽繘琛屽鐓х爺绌讹紝鎶ュ憡
濡備笅銆?/p>
1
璧勬枡涓庢柟娉?/p>
1.1
涓�鑸祫鏂?/p>
2009
骞?/p>
6
鏈堣嚦
2011
骞?/p>
7
鏈堝湪鎴戦櫌闂ㄨ瘖鍜屼綇闄㈡不鐤楃殑鎶戦儊鐥囨偅鑰呬负鐮旂┒瀵硅薄銆傚叆缁勬爣鍑嗭細
绗﹀悎涓浗绮剧闅滅鍒嗙被涓庤瘖鏂爣鍑嗙
3
鐗?/p>
(CCMD-3)
鎶戦儊鍙戜綔璇婃柇鏍囧噯銆傛眽瀵嗗皵椤挎姂閮侀噺琛?/p>
(HAMD)24
椤硅瘎鍒?/p>
鈮?0
鍒嗭紱鎺掗櫎鑽墿婊ョ敤鍜屼弗閲嶈函浣撶柧鐥呰�呫�傚叡
60
渚嬶紝闅忔満鍒嗘垚涓ょ粍銆傝タ閰炴櫘
鍏扮粍
30
渚嬶紝鐢?/p>
14
渚嬶紝濂?/p>
16
渚嬶紱骞撮緞
18
锝?/p>
58
宀侊紝骞冲潎
(30.6卤
13.8)
宀侊紱
HAMD
鎬诲垎
(29.60卤
6.58)
鍒嗭紱姹夊瘑灏旈】鐒﹁檻閲忚〃
(HAMA)
鎬诲垎
(25.94卤
8.63)
鍒嗭紱涓村簥鐤楁晥鎬昏瘎閲忚〃鐥呮儏涓ラ噸绋嬪害
(CGI-SI)
璇勫垎
(5.86卤
1.64)
鍒嗭紱闃虫�у鏃忓彶
5
渚嬶紱鍗曠浉鎶戦儊
22
渚嬶紝鍙岀浉鎶戦儊
8
渚嬨�傛枃鎷夋硶杈涚粍
30
渚嬶紝鐢?/p>
12
渚嬶紝濂?/p>
18
渚嬶紱骞撮緞
17
锝?/p>
60
宀侊紝骞冲潎
(32.78卤
11.58)
宀侊紱
HAMD
鎬诲垎
(29.57卤
4.56)
鍒嗭紱
HAMA
鎬诲垎
(24.30卤
7.84)
鍒嗭紱
CGI-SI(5.80卤
1.62)
鍒嗭紱闃虫�у鏃忓彶
4
渚嬶紱鍗曠浉鎶戦儊
24
渚嬶紝鍙岀浉鎶戦儊
6
渚嬨�備袱缁勪互涓婂悇椤瑰樊寮傚潎鏃犵粺璁″鎰忎箟
(P
鍧?/p>
>0.05)
銆?/p>
1.2
鏂规硶
缁忚繃
1
鍛ㄦ竻娲楁湡銆傚垵濮嬪墏閲忚タ閰炴櫘鍏版瘡鏃ユ櫒鏈?/p>
20 mg
锛涙枃鎷夋硶杈?/p>
25 mg/d
锛?/p>
2
娆?/p>
/d
銆?/p>
2
鍛ㄥ唴
鍔犺嚦鏈夋晥娌荤枟閲忥紝瑗块厼鏅叞
20
锝?/p>
40 mg/d
锛屾枃鎷夋硶杈?/p>
75
锝?/p>
225 mg/d
锛屽钩鍧?/p>
(150卤
35)mg/d
銆傜枟绋?/p>
8
鍛ㄣ�備笉鍚堢敤鍏朵粬鎶楁姂閮佸墏鍜屾姉绮剧鐥呰嵂銆傚け鐪犺�呭彲鐭湡鍚堢敤灏忓墏閲忚嫰浜屾爱鍗撶被鑽�傞噰鐢?/p>
HAMD
銆?/p>
HAMA
銆佸壇鍙嶅簲閲忚〃
(TESS)
鍦ㄦ不鐤楀墠鍙婃不鐤?/p>
2
銆?/p>
4
銆?/p>
6
銆?/p>
8
鍛ㄨ繘琛岃瘎瀹氥�傜枟鏁堟寜
HAMD
鍑忓垎鐜囷紝鍑忓垎鐜?/p>
鈮?5%
涓虹棅鎰堬紝
50%
锝?/p>
74%
涓烘樉钁楄繘姝ワ紝
25%
锝?/p>
49%
涓鸿繘姝ワ紝