[0590]
銆婄粏鑳炵敓鐗╁銆?/p>
绗簩娆′綔涓?/p>
[
璁鸿堪棰?/p>
]
浠?/p>
cAMP
淇″彿閫氳矾涓轰緥璇︾粏璇存槑
G
铔嬬櫧鍋惰仈鍙椾綋鎵�浠嬪鐨勭粏鑳炰俊鍙烽�氳矾锛?/p>
鍙傝�冪瓟妗堬細
鍦?/p>
cAMP
淇″彿閫斿緞涓紝
缁嗚優澶栦俊鍙蜂笌鐩稿簲鍙椾綋缁撳悎锛?/p>
璋冭妭
AC
娲绘�э紝
閫氳繃绗簩淇′娇
cAMP
姘村钩鐨勫彉鍖栵紝灏嗚優澶栦俊鍙疯浆鍙樹负鑳炲唴淇″彿銆?/p>
锛?/p>
1
锛?/p>
cAMP
淇″彿閫氳矾鐨勭粍鍒嗭細
鈶犮�佹縺娲诲瀷婵�绱犲彈浣擄紙
Rs
锛夋垨鎶戝埗鍨嬫縺绱犲彈浣擄紙
Ri
锛夛紱
鈶°�佹椿鍖栧瀷璋冭妭铔嬬櫧锛?/p>
Gs
锛夋垨鎶戝埗鍨嬭皟鑺傝泲鐧斤紙
Gi
锛夛紱
鈶€�佽吅鑻烽吀鐜寲閰讹紙
AC
锛夛細鏄浉瀵瑰垎瀛愰噺涓?/p>
150KD
鐨勭硸铔嬬櫧锛岃法鑶?/p>
12
娆°�傚湪
Mg2+
鎴?/p>
Mn2+
鐨勫瓨鍦ㄤ笅锛岃吅鑻烽吀鐜寲閰跺偓鍖?/p>
ATP
鐢熸垚
cAMP
銆?/p>
鈶ｃ�佽泲鐧芥縺閰?/p>
A
锛?/p>
PKA
锛夛細鐢变袱涓偓鍖栦簹鍩哄拰涓や釜璋冭妭浜氬熀缁勬垚锛屽湪娌℃湁
cAMP
鏃讹紝浠?/p>
閽濆寲澶嶅悎浣撳舰寮忓瓨鍦ㄣ�?/p>
鈶ゃ�佺幆鑵鸿嫹閰哥７閰镐簩閰叾锛?/p>
cAMP phosphodiesterase
锛夛細鍙檷瑙?/p>
cAMP
鐢熸垚
5'-AMP
锛?/p>
璧风粓姝俊鍙风殑浣滅敤
锛?/p>
2
锛夈�?/p>
Gs
璋冭妭妯″瀷锛?/p>
璇ヤ俊鍙烽�斿緞娑夊強鐨勫弽搴旈摼鍙〃绀轰负锛氭縺绱犫啋G
铔嬬櫧鑰﹁仈鍙椾綋鈫扜
铔嬬櫧鈫掕吅鑻烽吀鐜寲閰?/p>
鈫抍AMP鈫掍緷璧?/p>
cAMP
鐨勮泲鐧芥縺閰?/p>
A鈫掑熀鍥犺皟鎺ц泲鐧解啋鍩哄洜杞綍
锛?/p>
3
锛夈�?/p>
Gi
璋冭妭妯″瀷锛?/p>
Gi
瀵硅吅鑻烽吀鐜寲閰剁殑鎶戝埗浣滅敤鍙�氳繃涓や釜閫斿緞锛?/p>
鈶犻�氳繃
伪
浜氬熀涓庤吅鑻烽吀鐜寲閰剁粨鍚堬紝
鐩存帴鎶戝埗閰剁殑娲绘�э紱
鈶￠�氳繃
尾
纬
浜氬熀澶嶅悎鐗╀笌娓哥
Gs
鐨?/p>
伪
浜氬熀缁撳悎锛?/p>
闃绘柇
Gs
鐨?/p>
伪
浜氬熀瀵硅吅鑻烽吀鐜寲閰剁殑娲诲寲銆?/p>
[
璁鸿堪棰?/p>
]
鍙椾綋浠嬪鐨勫唴鍚炰腑
,
鍐呭悶娉′腑鐨勯厤浣撱�佸彈浣撳拰鑶滄垚鍒嗙殑鍘诲悜濡備綍
?
鍙傝�冪瓟妗堬細
绛旓細
鍦ㄥ彈浣撲粙瀵肩殑鍐呭悶浣滅敤涓?/p>
,
闅忓唴鍚炴场杩涘叆缁嗚優鍐呯殑鐗╄川鍙垎涓轰笁澶х被鈭堕厤浣?/p>
(
鐚庣墿
)
銆?/p>
鍙椾綋鍜岃啘缁勫垎
,
瀹?/p>
浠湁鐫�涓嶅悓鐨勫幓鍚?/p>
: