銆婅嵂鍓傚銆?/p>
绗?/p>
1
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绗崄涓夌珷
缁忕毊缁欒嵂鍒跺墏
绗竴鑺?/p>
姒傝堪
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绠″惛鏀惰繘鍏ヤ綋寰幆锛?/p>
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銆?/p>
骞夸箟鐨勭粡鐨粰鑽埗鍓傚寘鎷蒋鑶忓墏銆佺‖鑶忓墏銆佽创鍓傦紝杩樺彲浠ユ槸娑傚墏鍜屾皵闆惧墏绛夈�?/p>
鐙箟鐨勭粡鐨粰鑽埗鍓備竴
鑸槸鎸囪创鍓傦紝
閫氬父璧峰叏韬不鐤椾綔鐢?/p>
锛屼篃绉扮粡鐨粰鑽郴缁?/p>
锛?/p>
transdermal
drug
delivery
system
锛?/p>
绠�绉?/p>
TDDS
锛夈�?/p>
TDDS
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鐢ㄦ櫘閫氬彛鏈嶅埗鍓傜浉姣旓紝鍏跺叿鏈変互涓嬩紭鐐癸細
锛?/p>
1
锛夊彲閬垮厤鑲濊剰鐨勯杩囨晥搴斿拰鑳冭偁閬撳鑽墿鐨勯檷瑙ｏ紝鍑忓皯浜嗚儍鑲犻亾缁欒嵂鐨勪釜浣撳樊寮傦紱
锛?/p>
2
锛夊彲浠ュ欢闀胯嵂鐗╃殑浣滅敤鏃堕棿锛屽噺灏戠粰鑽鏁帮紱
锛?/p>
3
锛夊彲浠ョ淮鎸佹亽瀹氱殑琛�鑽祿搴︼紝閬垮厤鍙ｆ湇缁欒嵂寮曡捣鐨勫嘲璋风幇璞★紝闄嶄綆浜嗕笉鑹弽搴旓紱
锛?/p>
4
锛変娇鐢ㄦ柟渚匡紝鍙殢鏃朵腑鏂粰鑽紝閫傜敤浜庡┐鍎裤�佽�佷汉鍜屼笉瀹滃彛鏈嶇殑鐥呬汉銆?/p>
TDDS
铏界劧鏈変笂杩颁紭鐐癸紝浣嗕篃瀛樺湪浠ヤ笅鍑犳柟闈笉瓒筹細
锛?/p>
1
锛夌敱浜庣毊鑲ょ殑
灞忛殰浣滅敤锛屼粎闄愪簬鍓傞噺灏忚嵂鐞嗕綔鐢ㄥ己鐨勮嵂鐗?/p>
锛?/p>
锛?/p>
2
锛夊ぇ闈㈢Н缁欒嵂锛屽彲鑳?/p>
瀵圭毊鑲や骇鐢熷埡婵�鎬у拰杩囨晱鎬?/p>
锛?/p>
锛?/p>
3
锛夊瓨鍦?/p>
鐨偆鐨勪唬璋笌鍌ㄥ簱浣滅敤
銆?/p>
浜屻�?/p>
TDDS
鐨勫熀鏈粍鎴?/p>
TDDS
鐨勫熀鏈粍鎴愬彲鍒嗕负
5
灞傦細鑳岃‖灞傘�佽嵂鐗╄串搴撳眰銆佹帶閲婅啘銆侀粡闄勫眰鍜屼繚鎶よ啘銆?/p>
鑳岃‖灞傝嵂鐗╄串搴撳眰鎺ч噴鑶?/p>
1.
鑳岃‖灞?/p>
涓�鑸槸涓�灞傛煍杞殑澶嶅悎閾濈當鑶滐紝鍘氬害绾︿负
9
渭
m
锛屽彲闃叉鑽墿娴佸け鍜屾疆瑙ｃ�?/p>
2.
鑽墿璐簱灞?/p>
鑽墿璐簱鏃㈣兘鎻愪緵閲婃斁鐨勮嵂鐗╋紝
鍙堣兘渚涚粰閲婅嵂鐨勮兘閲忋�?/p>
鍏剁粍鎴愭湁鑽墿銆?/p>
楂樺垎瀛愬熀璐ㄦ潗鏂欍�?/p>
閫忕毊淇冭繘鍓傜瓑銆?/p>
3.
鎺ч噴鑶?/p>
璇ヨ啘澶氫负鐢?/p>
EVA
鍜岃嚧瀛斿墏缁勬垚鐨勫井瀛旇啘銆?/p>
4.
榛忛檮灞?/p>
鏄敱鏃犲埡婵�鎬у拰杩囨晱鎬х殑榛忓悎鍓傜粍鎴愶紝濡傚ぉ鐒舵爲鑳躲�佹爲鑴傚拰鍚堟垚鏍戣剛绛夈�?/p>
5.
淇濇姢灞?/p>
涓洪檮鍔犵殑濉戞枡钖勮啘锛岀敤鏃舵挄鍘汇�?/p>
涓夈�?/p>
TDDS
鐨勭被鍨?/p>
TDDS
鍩烘湰鍙?/p>
鍒嗕负鑶滄帶閲婂瀷鍜岄鏋跺瀷涓ょ被
銆傝啘鎺ч噴鍨嬬粡鐨粰鑽埗鍓傛槸鎸囪嵂鐗╄鎺ч噴鑶滄垨鍏朵粬鎺ч噴鏉愭枡鍖?/p>
瑁规垚鍌ㄥ簱锛岀敱鎺ч噴鑶滄垨鎺ч噴鏉愭枡鐨勬�ц川鎺у埗鑽墿鐨勯噴鏀鹃�熺巼銆傞鏋跺瀷缁忕毊缁欒嵂鍒跺墏鏄嵂鐗╂憾瑙ｆ垨鍧囧寑鍒嗘暎