丝氨酸蛋白酶的相关研ç©?/p>
摘要ï¼?/p>
本文概述了丝氨酸蛋白酶的酶学基础,反应机制,
该酶抑制剂的设计及其应用ã€?/p>
丝氨酸蛋白酶是一个蛋白酶家族,它们的作用是断裂大分子蛋白质中的肽键,使之成为å°?/p>
分子蛋白质。其激活是通过活性中心一组氨基酸残基变化实现的,它们之中一定有一个是
丝氨酸(其名字的由来ï¼?/p>
。在哺乳类动物里面,丝氨酸蛋白酶扮演着很重要的角色,特别是
在消化,凝血和补体系统方面。正是由于该酶的特殊性质,使其在众多领域都有所应用ã€?/p>
关键字:
丝氨酸蛋白酶;酶学基础;反应机制;应用
Abstract
ï¼?/p>
This
article
provides
an
overview
of
the
serine
protease
enzyme,
reaction
mechanism,
the
design
and
application
of
enzyme
inhibitors.
Serine
protease is a protease family, their roles are to break large protein molecules in the
peptide
bond,
to
become
small
molecular
protein.
Its
activation
is
through
the
active center of a group of amino acid residues change, they must have a serine
(the origin of the name).
In mammal animal, serine proteases play a very important
role, especially in the digestion,
Coagulation and complement systems. Because of
the special nature of the enzyme, and it has been applied in many fields.
Keywords:
Serine
protease;
fundamentals
of
enzymology;
reaction
mechanism; application
绪论
丝氨酸蛋白酶是一类以丝氨酸为活性中心的重要的蛋白水解酶,在生物有机体中起着