榫欐簮鏈熷垔缃?/p>
http://www.qikan.com.cn
鍥涢」鍏嶇柅缁勫寲鏍囧織鐗╁湪璇婃柇鐢茬姸鑵轰钩澶寸姸鐧?/p>
涓殑涓村簥鎰忎箟
浣滆�咃細鏉庡ぉ涓�绛?/p>
鏉ユ簮锛氥�婁笂娴峰尰鑽�?/p>
2014
骞寸
10
鏈?/p>
鎽?/p>
瑕?/p>
鐩殑锛氭帰璁?/p>
Ki67
鏍告姉鍘?/p>
鍏抽敭璇?/p>
鐢茬姸鑵轰钩澶寸姸鐧?/p>
Ki67
鏍告姉鍘?/p>
鐢茬姸鑵鸿浆褰曞洜瀛?/p>
-1
浜鸿〃鐨敓闀垮洜瀛愬彈浣?/p>
-2
浜洪楂撲笂鐨?/p>
缁嗚優
-1
涓浘鍒嗙被鍙凤細
R736.1
鏂囩尞鏍囪瘑鐮侊細
A
鏂囩珷缂栧彿锛?/p>
1006-1533
锛?/p>
2014
锛?/p>
10-0024-04
ABSTRACT Objective
锛?/p>
To investigate the clinical value of differentiation of the papillary
thyroid carcinoma
锛?/p>
PTC
锛?/p>
from the benign thyroid nodules with Ki67 nuclear antigen
锛?/p>
Ki67
锛夛紝
thyroid transcription factor-l
锛?/p>
TTF-1
锛夛紝
human epidermal growth factor receptor type-2
锛?/p>
HER-
2/neu
锛夛紝
and human bone marrow endothelial cell-1
锛?/p>
HBME-1
锛?/p>
. Methods
锛?/p>
The parafin sections
of 180 cases with PTC and 190 cases with the benign thyroid nodules were retrospectively analyzed.
The levels of Ki67
锛?/p>
TTF-1
锛?/p>
HBME-1 and HER-2/neu were determined immunohistochemically.
Results
锛?/p>
The positive rates of the expressions of 4 markers were higher in PTC specimens than in the
benign thyroid nodules specimens
锛?/p>
P=0.000
锛?/p>
. When using a single marker
锛?/p>
the detection of HER-
2/neu had the most sensitivity
锛?/p>
79.4%
锛?/p>
and that of HBME-1 the most specificity
锛?/p>
96.8%
锛?/p>
. The
detection combined with Ki67
锛?/p>
HER-2/neu and HBME-1 had the most sensitivity
锛?/p>
89.8%
锛?/p>
. The
detection combined with HER-2/neu+ TTF-1 and HER-2/neu+TTF-1+HBME-1 had the same
specificity
锛?/p>
99.4%
锛?/p>
P
KEY WORDS papillary thyroid carcinoma
锛?/p>
Ki67 nuclear antigen
锛?/p>
thyroid transcription
factor-l
锛?/p>
human epidermal growth factor receptor type-2
锛?/p>
human bone marrow endothelial cell-1
鐢茬姸鑵轰钩澶寸姸鐧岋紙
papillary thyroid carcinoma
锛?/p>
PTC
锛夋槸鏈�甯歌鐨勭敳鐘惰吅鎭舵�ц偪鐦わ紝鍏跺彂
鐥呯巼鍦ㄨ繎骞村憟鏄庢樉涓婂崌瓒嬪娍銆傝�堕瞾澶у鍖诲闄㈢殑鐮旂┒琛ㄦ槑锛屼粠
2001
骞村埌
2008
骞达紝缇庡浗
PTC
鐨勫彂鐥呯巼澧炲姞浜?/p>
60.8%[1]
銆?/p>
PTC
缁嗚優缁勭粐瀛︾殑鐥呯悊璇婃柇涓昏鍩轰簬闀滀笅瑙傚療锛岄櫎浜嗛偅浜涚己灏戝吀鍨?/p>
闀滀笅鐗瑰緛鐨勭梾渚嬶紝澶ч儴鍒?/p>
PTC
鑳藉鏄撶‘璇?/p>
[2]
銆傚厤鐤粍鍖栨爣蹇楃墿鏈夊姪浜庨壌鍒?/p>
PTC
鍜岀敳鐘惰吅鑹�?/p>
鑲跨槫銆傚凡鏈夌爺绌惰〃鏄庯紝瀵圭粍缁囩粏鑳炲鏍囨湰琛屼笉鍚岀粏鑳炶铔嬬櫧鐨勫厤鐤粍鍖栨煋鑹诧紝鍙綔涓?/p>
PTC
璇?/p>
鏂殑杈呭姪鎶�鏈?/p>
[2]
銆備絾鏄紝瀵逛互鎻愰珮
PTC
璇婃柇鍑嗙‘鎬т负鐩殑鐨勫绉嶆爣蹇楃墿鑱斿悎妫�娴嬫柟娉曪紝鐩墠
灏氬瓨鍦ㄤ簤璁恒�?/p>
Nga
绛?/p>
[3]
鐮旂┒璁や负锛屽湪
PTC
缁嗚優瀛﹁瘖鏂腑锛岃仈鍚堝簲鐢ㄤ汉楠ㄩ珦鍐呯毊缁嗚優
-1
锛?/p>
human
bone marrow endothelial cell-1
锛?/p>
HBME-1
锛夊拰缁嗚優瑙掕泲鐧?/p>
19
锛?/p>
cytokeratin-19
锛?/p>
CK-19
锛夌殑鏁忔劅
鎬у拰鐗瑰紓鎬у潎涓?/p>
100.0%
锛屼絾鍙︽湁鐮旂┒琛ㄦ槑锛岃仈鍚堝簲鐢ㄤ袱鑰呯殑鏁忔劅鎬у拰鐗瑰紓鎬у垯鍒嗗埆浣庤嚦
62.0%
鍜?/p>
95.0%
銆?/p>