榫欐簮鏈熷垔缃?/p>
http://www.qikan.com.cn
涓婄毊
-
闂磋川缁嗚優杞寲鐨勫垎瀛愭満鍒跺強鍏跺湪鑲跨槫
杞Щ涓殑浣滅敤
浣滆�咃細绗
鏉ユ簮锛氥�婁腑澶栧尰瀛︾爺绌躲�?/p>
2011
骞寸
29
鏈?/p>
銆愭憳瑕併�戜笂鐨粏鑳為棿璐ㄨ浆鍖?/p>
(epithelial-mesenchymal transition
锛?/p>
EMT)
鏄叿鏈夋瀬鎬х殑涓婄毊缁?/p>
鑳炶浆鎹㈡垚涓哄叿鏈夌Щ琛岃兘鍔涚殑闂磋川缁嗚優骞惰幏寰椾镜琚拰杩佺Щ鑳藉姏鐨勮繃绋嬶紝瀹冨瓨鍦ㄤ簬浜轰綋澶氫釜鐢熺悊鍜?/p>
鐥呯悊杩囩▼涓�備笂鐨?/p>
-
闂磋川杞寲
(EMT)
鍦ㄦ伓鎬ц偪鐦ょ殑渚佃杞Щ杩囩▼涓捣鐫�鍏抽敭鐨勪綔鐢紝鐮旂┒
EMT
鐨勫鍙戝洜绱犲強鍏朵笅娓搁�氳矾鍦ㄨ偪鐦ょ敓闀裤�佷镜琚�佽浆绉讳腑鐨勪綔鐢紝闃绘柇杩欎竴鏈哄埗鐨勫彂鐢熷彂灞曪紝瀵规伓
鎬ц偪鐦ょ殑渚佃杞Щ鍓嶇殑鏃╂湡璇婃柇銆佹棭鏈熸不鐤楁湁鐫�闈炲父閲嶈鐨勬剰涔夈�?/p>
銆愬叧閿瘝銆戜笂鐨?/p>
-
闂磋川杞寲
(EMT)
锛涜偪鐦や镜琚紱鑲跨槫杞Щ锛涘垎瀛愭満鍒?/p>
EMT
鍦ㄥ尰瀛︿腑鏄竴绫荤敓鐞嗙粍缁囧彉鍖栫姸鍐碉紝鍏朵竴鑸槸涓婄毊缁嗚優鍦ㄧ壒娈婄殑鎯呭喌涓嬪彂鐢熷悜闂磋川
缁嗚優杞寲鐨勫舰寮忥紝杩欑杞寲鏈�澶х殑鐗圭偣鍦ㄤ簬澶卞幓涓婄毊缁嗚優琛ㄥ瀷銆佽幏寰楅棿璐ㄧ粏鑳炵壒鎬х瓑銆備粠鍖诲
鍙戝睍鍘嗗彶鐪嬶紝瀵逛簬
EMT
鐨勭爺绌跺彂鐜版渶鏃╁湪鍙戣偛鐢熺墿瀛︿腑锛岀爺绌朵汉鍛橀�氳繃缁嗚優瀹為獙鎬荤粨鍑轰簡鐩?/p>
鍏崇殑缁撹銆傜粡杩囬暱鏈熷疄楠屽彂鐜帮紝
EMT
瀵规伓鎬ц偪鐦や镜琚�佽浆绉汇�佸彉鍖栫殑褰卞搷杈冨ぇ锛岄拡瀵硅繖涓�
鐐癸紝鏈枃涓昏鐮旂┒浜?/p>
EMT
鐨勫彂鐢熸満鍒朵互鍙婂叾鍦ㄨ偪鐦や镜琚浆绉讳腑鐨勭浉鍏冲奖鍝嶃�?/p>
1EMT
鐨勬蹇?/p>
鍦ㄧ敓鐗╁鐮旂┒宸ヤ綔娣卞叆寮�灞曠殑鍚屾椂锛屼汉浠浜庡悇绉嶇敓鐗╁鐞嗗康鐨勮璇嗘洿鍔犲厖鍒嗐�?/p>
1982
骞达紝
Garry Greenburg
锛?/p>
1
锛藉拰
Hay
绛夛蓟
2
锛介�氳繃浣撳缁嗚優瀹為獙鑾峰緱浜嗗法澶х殑鏀惰幏锛屽彂鐜版櫠鐘朵綋涓?/p>
鐨粏鑳炲湪鑳跺師鍑濊兌涓骇鐢熸垚浼冻鑰屽嚭鐜板嚭闂磋川缁嗚優鐨勭姸鎬侊紝
EMT
姒傚康鐢辨琚彁鍑烘潵銆傝嫢涓婄毊
缁嗚優浜х敓
EMT
涔嬪悗锛屽舰鎬佷笂鐢辩珛鏂瑰舰涓婄毊缁嗚優鍒欒浆鍖栦负姊舰鐨勯棿鍏呰川缁嗚優鐨勫舰鎬併�傚悓鏃讹紝杩?/p>
瑙傚療鍒颁笂鐨粏鑳炴爣蹇楃墿鐨勮〃杈句笅璋冩垨鑰呯己澶憋紝鍖呮嫭锛?/p>
E-
閽欓粡铔嬬櫧
(E-Cad)
銆侀粡铔嬬櫧銆佽铔嬬櫧銆?/p>
妗ョ矑鏂戣泲鐧界瓑锛涢棿璐ㄧ粏鑳炴爣璁扮墿鐨勮〃杈句笂璋冿紝鍖呮嫭锛氭尝褰㈣泲鐧姐�?/p>
N-
閽欓粡铔嬬櫧銆佺氦杩炶泲鐧姐�佽〃杈?/p>
涓婅皟銆?/p>
2EMT
鐨勫舰鎴愬強鑲跨槫杞Щ
瀵艰嚧
EMT
浜х敓鐨勫洜绱犳槸澶氫釜鏂归潰鐨勶紝鍏跺寘鎷細铔嬬櫧鍒嗗瓙銆佽浆褰曡皟鑺傚洜瀛愩�?/p>
MicroRNA
绛?/p>
鏂归潰鐨勫彉鍖栥�傝繖浜涢兘浼氱粰鎮ｈ�呯殑韬綋缁勭粐閫犳垚涓嶅埄褰卞搷锛屽鏄撲娇寰楄偪鐦ょ粏鑳炶琚嚮鑰屽嚭鐜拌浆
绉伙紝鐢辨澧炲姞浜嗗尰鐢熸不鐤楃殑闅惧害銆?/p>
2.1E-
閽欓粡铔嬬櫧
(E-cad)
閽欒繛鎺ョ礌灞炰簬涓婄毊缁勭粐涓殑缁嗚優闂磋法鑶滈粡杩炵硸铔嬬櫧鍒嗗瓙锛屽叾寰�寰�瑕?/p>
鍊熷姪浜?/p>
Ca2+
鎵嶈兘鍙戞尌浣滅敤銆傞挋杩炴帴绱犲潎鍙備笌浜嗙粏鑳為棿鐨勮繛鎺ワ紝鍖呮嫭锛?/p>
E-cad
銆?/p>
N-cad
銆?/p>
P-cad
涓?