鎶椾綋閰剁殑鐮旂┒杩涘睍
鎽樿锛?/p>
鎶椾綋閰舵槸鍏锋湁鍌寲娲绘�х殑
IgG
锛堝厤鐤悆铔嬬櫧锛?/p>
銆傜敱浜庡畠鍏煎叿鎶椾綋鐨勯珮搴﹂�夋嫨鎬у拰閰剁殑楂樻晥鍌?/p>
鍖栨�э紝
鍥犳鎶椾綋閰跺埗澶囨妧鏈殑寮�鍙戦绀虹潃鍙互浜轰负鐢熶骇閫傚簲鍚勭鐢ㄩ�斻�?/p>
鏂囩珷缁煎悎浠嬬粛浜嗘姉浣?/p>
閰剁殑鏉ユ簮銆佹彁鍙栦笌鍒嗙绾寲鏂规硶銆佸垎瀛愪慨楗般�佸浐瀹氬寲鎶�鏈�佸簲鐢ㄥ強鐮旂┒鐨勬渶鏂拌繘灞曠瓑銆?/p>
鍏抽敭璇嶏細
鎶椾綋閰躲�佹潵婧愩�佹彁鍙栦笌鍒嗙銆佸垎瀛愪慨楗般�佸浐瀹氬寲鎶�鏈�佸簲鐢?/p>
Advance in the Research of Abzyme
Abstract:
Abzymesis
a
kind
of
immunoglobulin
with
catalytic.
Because
it
has
high
selectivityand
amazing
diversity
as
antibodies
and
highly
catalytic
,it
is
anticipated
that
usingabzymespreparation
technologyone
can
obtain
any
kind
of
tailor-made
biocatalysts,including
those
not
occurred
in
nature,for
various
kinds
of
practicalapplication.This
article
summarizes
the
resourceextraction
and
separation,molecule
modifying,technology
of
immobilization
,
the
applications
and
the
research strategies of theabzymes.
Key words:
abzymes;resource ;extraction and separation ; molecule modifying ; technology
of immobilization ; applications
1.
鎶椾綋閰剁殑鏉ユ簮涓庢柟娉?/p>
鎶椾綋閰剁殑鏉ユ簮鍙互杩愮敤澶氱鏂规硶鏉ヨ璁″拰鍒跺锛?/p>
涓昏鏈夎瀵兼硶銆?/p>
宸ョ▼鎶椾綋鍌寲娉曘�?/p>
鍏嬮殕
鍏嶇柅鍙嶅簲鍥犲瓙鍩哄洜娉曘�佹嫹璐濇硶銆?/p>
鍖栧淇グ娉曘�?/p>
缁嗚優铻嶅悎娉曠瓑澶氱鏂规硶锛?/p>
鍏朵腑灏や互鍓嶄袱绉嶆柟娉?/p>
鐨勫簲鐢ㄦ渶涓烘櫘閬嶃�?/p>
1. 1
璇卞娉?/p>
杩欐槸鎶椾綋閰剁殑浼犵粺鍒跺鏂规硶锛?/p>
閫夋嫨鍚堥�傜殑鍙嶅簲杩囨浮鎬佺被浼肩墿浣滀负鍖栧妯″瀷鐗╋紝
涓庤浇浣撹泲
鐧藉伓鑱斿悗鍏嶇柅鍔ㄧ墿锛?/p>
浣垮涓讳骇鐢熸姉浣擄紝
鍐嶅埄鐢ㄦ潅浜ょ槫鎶�鏈潵绛涢�夊拰鍒嗙锛?/p>
寰楀埌鍏锋湁鍌寲娲绘�?/p>
鐨勫崟鍏嬮殕鎶椾綋锛?/p>
灏辨槸鎶椾綋閰躲�?/p>
鐢ㄥ崟鍏嬮殕鍖栫殑鏉備氦鐦ょ粏鑳炲氨鑳借繘琛屽崟鍏嬮殕鎶椾綋鐨勬墿澶х敓浜с�?/p>
鐢?/p>
浜庡鏁板弽搴旇繃娓℃�佺被浼肩墿鐨勫垎瀛愰噺杈冧綆
,
鍗冲崐鎶楀師鏈韩鐨勫厤鐤師鎬у緢寮憋紝
蹇呴』涓庢煇绉嶈浇浣撳伓
鑱旀墠鑳借〃鐜板厤鐤師鎬с�傜洰鍓嶆渶甯歌鐨勮浇浣撹泲鐧藉寘鎷墰琛�娓呰泲鐧藉拰閽ュ瓟琛�钃濊泲鐧界瓑銆?/p>
鎵�寰楀埌鐨勬姉浣撻叾鐨勫偓鍖栬兘鍔涚殑楂樹綆
,
鍦ㄥ緢澶х▼搴︿笂鍙栧喅浜庡弽搴旇繃娓℃�佺被浼肩墿
,
鍗冲崐鎶楀師
鐨勮璁¤姹傞�氳繃鍗婃姉鍘熺殑璁捐
,
浜х敓鏈�浼樺寲鐨勬姉浣撳偓鍖栧墏
,
瀹炵幇涓庡厤鐤悆铔嬬櫧缁撳悎鍙ｈ鐨勪簰
琛ョ幇宸插簲鐢ㄧ殑璁捐绛栫暐鍖呮嫭
:
杩囨浮鎬佺被浼肩墿璁捐銆?/p>
璇卞鍜岃浆鎹㈣璁°�?/p>
鍙嶅簲鍏嶇柅銆?/p>
鈥滄綔杩囨浮鎬佲�?/p>
鍗婃姉鍘熻璁＄瓑銆?/p>
1.2
宸ョ▼鎶椾綋鍌寲娉?/p>
宸ョ▼鎶椾綋鍌寲娉曞�熷姪鍩哄洜宸ョ▼鍜岃泲鐧借川宸ョ▼鎶�鏈紝
瀵规姉浣撹繘琛屾敼閫狅紝
寮曞叆鍌寲娲绘�у皢鍌?/p>
鍖栧熀鍥犲紩鍏ュ埌鐗瑰紓鎶椾綋鐨勬姉鍘熺粨鍚堜綅鐐逛笂锛?/p>
涔熷彲浠ラ拡瀵规�у湴鏀瑰彉鎶椾綋缁撳悎鍖虹殑鏌愪簺姘ㄥ熀閰稿簭