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869
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729
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71
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25
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Staurosporine
鐨勮鐢熺墿
HDZ-115
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Xanthocillin X
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4
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1
鏍繁娴锋捣娲嬫斁绾胯弻
SCSIO ZH66
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Grincamycin
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Lobophorin
鐨勭敓鐗╁悎鎴愬熀鍥犵皣锛屽畬鎴愪簡
Grincamycin
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marinacarboline
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lobophorin
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5
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鐢熸�佹晥搴?/p>
鐢熺墿鍚堟垚
鏂板瀷閰?/p>
Abstract
锛?/p>
This 2013 annual report of the National High Technology Research and Development
Program of China 鈥淒iscovery and Development of Bioactive Substrates from the Deep
-sea
Microorganisms鈥?nbsp;includes the following contents
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1
锛?/p>
869 strains have been purified
锛?/p>
separated
and preserved from the deep sea sediment and 729 of them have been determined with their
phylogenetic position. 237 strains have been purified and separated from deep sea water samples
锛?/p>
and 168 of them have been completed with their bacteria sequencing studies
锛?/p>
there is a potential new
genus level taxa in them
锛?/p>
锛?/p>
2
锛?/p>
21 Stains of deep-sea microbes have been investigated for their
secondary metabolisms. 186 compounds have been isolated and identified and 71 of them are new
compounds
锛?/p>
including a novel cyclic tetrapeptide. 25 compounds were found to show significant
pharmacological activities. Detained pharmacological studies of HDZ-115
锛?/p>
derivative of
staurosporine
锛?/p>
and Xanthocillin X show that these two lead compounds are worthy of further drug
assessment.
锛?/p>
3
锛?/p>
Some lipopeptides show antagonistic activities toward the tested plant fungal
pathogens. Several active substances are obtained with their antifouling activities
锛?/p>
and one of them
shows a good application value in the antipollution experiments in sea.
锛?/p>
4
锛?/p>
The genome of the deep
sea actinomycete SCSIO ZH66 has been scanned
锛?/p>
gene clusters responsible for grincamycin and