鈥︹�︹�︹�︹�︹�︹�︹�︹�︹�︹�︹�︹�︹�︹�︹�︹�︹�︹�︹�︹�︹�︹�︽渶鏂拌祫鏂欐帹鑽愨�︹�︹�︹�︹�︹�︹�︹�︹�︹�︹�︹�︹�︹�︹�︹�︹�︹�︹�?/p>
1
鑽墿鎬ц倽鎹熶激璇婃不鎸囧崡
涓崕鍖诲浼氳倽鐥呭鍒嗕細鑽墿鎬ц倽鐥呭缁?/p>
2015
骞?/p>
10
鏈?/p>
涓�銆佽儗鏅?/p>
鑽墿鎬ц倽鎹熶激锛?/p>
drug-induced liver injury
锛?/p>
DILI
锛夋槸鎸囩敱鍚勭被澶?/p>
鏂规垨闈炲鏂圭殑鍖栧鑽墿銆?/p>
鐢熺墿鍒跺墏銆?/p>
浼犵粺涓嵂
锛?/p>
TCM
锛?/p>
銆?/p>
澶╃劧鑽?/p>
锛?/p>
NM
锛?/p>
銆?/p>
淇濆仴鍝侊紙
HP
锛?/p>
銆佽喅椋熻ˉ鍏呭墏锛?/p>
DS
锛夊強鍏朵唬璋骇鐗╀箖鑷宠緟鏂欑瓑鎵�璇卞彂鐨?/p>
鑲濇崯浼?/p>
[1-4]
銆?/p>
TCM
鏄寚鍦ㄦ垜鍥戒腑鍖荤瓑浼犵粺姘戞棌鍖昏嵂瀛︾悊璁烘寚瀵间笅鐢?/p>
浜у拰浣跨敤鐨勫悇绉嶈崏鑽拰闈炶崏鑽被鐨勪腑鑽潗銆侀ギ鐗囧拰澶嶆柟涓垚鑽紝
NM
鏄寚搴旂敤鐜颁唬鍖昏嵂鐞嗚鍜屾妧鏈埗澶囩殑澶╃劧鑽敤鐗╄川鍙婂叾鍒跺墏銆?/p>
DILI
鏄渶甯歌鍜屾渶涓ラ噸鐨勮嵂鐗╀笉鑹弽搴旓紙
ADR
锛変箣涓�
[1,5]
锛岄噸鑰呭彲鑷存�ユ�?/p>
鑲濊“绔紙
ALF
锛夌敋鑷虫浜?/p>
[6]
銆傝縿浠婁粛缂轰箯绠�渚裤�佸瑙傘�佺壒寮傜殑璇婃柇鎸?/p>
鏍囧拰鐗规晥娌荤枟鎵嬫銆?/p>
缇庡浗浜?/p>
2003
骞村垱绔嬩簡
DILI
鍗忎綔缃戠粶锛?/p>
DILIN
锛夛紝
2004
骞村惎鍔ㄤ簡
DILIN
鍓嶇灮鎬х爺绌讹紙
DILIN-PS
锛?/p>
[2]
銆?/p>
2012
骞村彂甯冧簡
LiverTox
缃戠珯
锛?/p>
http://www.livertox.nih.gov
锛?/p>
[7]
锛?/p>
2014
骞寸編鍥借儍鑲犵梾瀛︿細
锛?/p>
ACG
锛?/p>
鍩轰簬鏈夐檺璇佹嵁鍑哄彴浜嗗叏鐞冮涓拡瀵圭壒寮傝川鍨?/p>
DILI
锛?/p>
IDILI
锛夌殑涓村簥鎸?/p>
鍗?/p>
[3]
銆傛垜鍥戒簬
2014
骞村彂甯冧簡涓浗
HepaTox
缃戠珯
锛?/p>
http://www.hepatox.org
锛?/p>
[8]
銆?/p>
LiverTox
鍜?/p>
HepaTox
缃戠珯鍒嗗埆璁板綍
浜嗚繎
700
绉嶅拰
400
浣欑甯歌鑽墿鐨勮倽鎹熶激淇℃伅锛?/p>
涓轰复搴婂尰鐢熸厧閲嶅鏂瑰叿
鏈夋綔鍦ㄨ倽姣掓�х殑鑽墿鍙婅瘎浼板叾椋庨櫓鍜屾敹鐩婃彁渚涗簡閲嶈渚濇嵁銆?/p>