榫欐簮鏈熷垔缃?/p>
http://www.qikan.com.cn
鍩轰簬
Wnt
閫氳矾鍔犲懗涔屾涓稿缁撹偁鐧岀殑鎶戝埗
鏈哄埗
浣滆�咃細寮犵劧
鏉庣礌濞?/p>
闄堟褰?/p>
鏉ㄥ潳
鏉ユ簮锛氥�婁笘鐣岀潯鐪犲尰瀛︽潅蹇椼�?/p>
2018
骞寸
08
鏈?/p>
鎽樿
鐩殑锛氭帰璁ㄥ姞鍛充箤姊呬父鎶戝埗缁撹偁鐧岀殑鏁堟灉骞跺垎鏋愬叾浣滅敤鏈哄埗銆傛柟娉曪細閫夊彇
BALB/c
闆?/p>
鎬у皬榧?/p>
30
鍙紝闅忔満鍒嗕负绌虹櫧缁勩�佹ā鍨嬬粍鍜屼箤姊呬父缁勶紝姣忕粍
10
鍙�傚叾涓┖鐧界粍灏忛紶涓嶆帴鍙楀共棰?/p>
鎺柦锛屼箤姊呬父缁勮繘琛屼箤姊呬父鐓庡墏鐏岃儍澶勭悊锛岀┖鐧界粍鍙婃ā鍨嬬粍鎺ュ彈绛夊墏閲忕敓鐞嗙洂姘寸亴鑳冿紝鍧囧共棰?/p>
28 d
锛岃瀵熻偪鐦や綋绉殑鍙樺寲銆佸皬榧犵殑浣撻噸鍙婂瓨娲荤巼銆佽偪鐦ょ粍缁?/p>
Wnt
銆?/p>
JNK
姘村钩鍙樺寲銆傜粨鏋滐細妯?/p>
鍨嬬粍涓庝箤姊呬父缁勫皬榧犺偪鐦や綋绉緝骞查鍓嶅潎鏈夊鍔犵殑瓒嬪娍锛屽叾涓箤姊呬父缁勫鍔犵殑閫熷害杈冩參锛屽苟鍦?/p>
骞查
28 d
鍚庤偪鐦ょ粍缁囨湁鍑忓皬鐨勮秼鍔匡紱骞查
28 d
绌虹櫧缁勫皬榧犱綋閲嶄笌鍒濆浣撻噸鐩歌繎锛屾ā鍨嬬粍鍙婁箤
姊呬父缁勫皬榧犱綋閲嶆槑鏄句笅闄嶏紝鍏朵腑妯″瀷缁勮緝涔屾涓哥粍涓嬮檷鏄庢樉锛屽樊寮傛湁缁熻瀛︽剰涔夛紙
P
鍏抽敭璇?/p>
缁撹偁鐧岋紱涔屾涓革紱鑲跨槫浣撶Н锛?/p>
Wnt
铔嬬櫧锛?/p>
JNK
铔嬬櫧锛涙姉鑲跨槫锛涗镜琚兘鍔涳紱鐤楁晥
Abstract Objective
锛?/p>
To investigate the colon cancer inhibition of modified wumei boluses and to
analyze some of the action mechanism. Methods
锛?/p>
A total of 30 BALB/c male mice were randomly
divided into blank group
锛?/p>
model group and wumei boluses group
锛?/p>
with 10 in each group. The mice
of blank group did not accept intervention measures
锛?/p>
and wumei boluses group had lavage treatment
of wumei boluses decoction. Blank group and model group received isodose physiological saline
lavage. All the groups had 28 d intervention. The changes of tumor volume
锛?/p>
weight of mice and
survival rate
锛?/p>
concentration changes of Wnt
锛?/p>
JNK in the tumor tissue were observed. Results
锛?/p>
1
锛?/p>
the mice tumor volume increased in the model group and wumei boluses group than before the
intervention
锛?/p>
and the increase in the wumei boluses group was more slowly. The tumor tissue had a
tendency to decrease after 28 d of intervention. 2
锛?/p>
After 28 days of the intervention
锛?/p>
the mice
weight in the blank group was similar to the initial weight
锛?/p>
and the mice weight of the model group
and the wumei boluses decreased obviously. The decrease of model group was more significantly than
that in the wumei boluses group
锛?/p>
P
Key Words Colon cancer
锛?/p>
Wumei boluses
锛?/p>
Wnt
锛?/p>
JNK
锛?/p>
Antitumor
锛?/p>
Invasiveness
锛?/p>
Curative effect
涓湒鍒嗙被鍙凤細
R289.5
锛?/p>
R735.3
鏂囩尞鏍囪瘑鐮侊細
Adoi
锛?/p>
10.3969/j.issn.1673-7202.2018.08.038
缁撹偁鐧屾槸涓村簥甯歌鐨勬秷鍖栭亾鎭舵�ц偪鐦わ紝闅忕潃浜轰滑鐢熸椿鏂瑰紡浠ュ強楗缁撴瀯鐨勬敼鍙橈紝缁撹偁鐧岀殑
鍙戠梾鐜囨棩鐩婂鍔狅紝鍙戠梾骞撮緞浜︽湁骞磋交鍖栬秼鍔?/p>
[1-2]
銆傛湁鐮旂┒鏄剧ず缁撹偁鐧屼粠鑹�х梾鍙樿浆鍙樻垚鐧屽墠鐥?/p>
鍙橈紝鏈�缁堝彂灞曟垚鎭舵�х梾鍙樿繃绋嬩腑
Mnt
淇″彿閫氳矾琚紓甯告縺娲?/p>
[3]
銆?/p>
Mnt
淇″彿閫氳矾涓庢満浣撴甯歌儦鑳?/p>
鍙戣偛瀵嗗垏鐩稿叧锛岃閫氳矾鐨勬爣蹇楄泲鐧界浉浜掑奖鍝嶏紝浠庤�屼粙瀵肩浉鍏冲熀鍥犺浆褰曪紝鏄粨鑲犵檶鍙戠敓鐨勫叧閿洜