老年性痴呆 Alzheimer’s Disease
Introduction 简介
AD, first characterized by Alois Alzheimer in 1907, is a gradually progressive dementia affecting both
Alzheimer ['?lz'?m?]
n. 老年痴呆症（等于Alzheimer’s
cognition
and
behavior. 渐进性痴呆有认知和行为障碍。
The exact pathophysiologic mechanism
underlying AD are not entirely known. 病理生理机制不清。
Although drugs may reduce Alzheimer’s symptoms for a time, the disease is eventually fatal.药物只能暂时改变症状，疾病将最终威胁生命。
The disease profoundly affects the family as well as the patient. 疾病不仅影响病人并将影响整个家庭生活质
量。
disease ）
progressive [pr?'gres?v] n. 改革论者；进步分子 adj. 进步的；先进的 dementia [d?'men??] n. [内科] 痴呆
cognition [k ? g'n??(?)n] n. 认识；知识；认识能力 behavior [bi'heivj?]
n. 行为，举止；态度；反应 pathophysiologic [,p?θ?,fizi?'l?d?ik] adj. 病理生理的 symptoms 基本翻译
n. [临床] 症状；症候；病徵 for a time 暂时；一段时期 fatal ['fe?t(?)l]
adj. 致命的；重大的；毁灭性的；命
中注定的 profoundly [pr?'fa?ndl?] adv. 深刻地；深深地；极度地
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Dementia 1 痴呆1 Dementia disorders
are defined
neuropsychiatric by
widespread
neuropsychiatric adj. 神经精神病学的
widespread ['wa?dspred; -'spred] adj. 普遍的，广泛的；分布广的 deficits
symptoms of memory loss and deficits in cognition and reasoning.痴呆是一种神经心理疾病，伴有广泛记忆缺失及认知和推理的障碍。
Dementia is a nonspecific term describing a significant decline in cognitive function regardless of cause.痴呆是一个非特异性名词，通常形容认知障碍，而不考虑病因。
Dementias, synonymous with the popular lay term “senility”, result from underlying disease, and are not part of normal aging.痴呆俗称为衰老，通常由于某种疾病引起，不是年龄增长而引起的。
n. [财政] 赤字，亏损（deficit的复数形式）
reasoning:推理，论证 nonspecific [,n?nspi'sifik] adj. [医] 非特异性的；非特殊的 regardless of 不顾，不管 synonymous with 与...同义
synonymous [s?'n?n?m?s]
adj. 同义的；同义词的；同义突变的 popular ['p?pj?l?]
adj. 流行的，通俗的；受欢迎的；大众的；普及的 lay [le?]
adj. 世俗的；外行的；没有经验的 n. 位置；短诗；花纹方向；叙事诗；性伙伴
vt. 躺下；产卵；搁放；放置；铺放；涂，敷
v. 躺；位于（lie的过去式） vi. 下蛋；打赌 senility [s?'n?l?t?]
n. [基医] 衰老；高龄；老态龙钟
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Dementia 2 痴呆2
Delirium differs from dementia in that it develops over a short period of time (hours to days), and involves an acute change in the level of consciousness in addition to a decline in cognition.谵妄状态区别于痴呆，由于发展迅速（几小时至几天），除有认知障碍外还有急剧的意识状态变化。
AD is the most common cause of dementia, accounting for over 60% of all
cases
of
late-life
cognitive
dysfunction.老年性痴呆是一种最常见的痴呆，60%的老年认知障碍均为老年性痴呆。
Epidemiology流行病学
Most cases present after age 65 (late-onset), but in about 5% of cases
onset can be age 40 (early-onset) 大多数65岁发病，但有5% 在40岁
左右发病。
An overall disease prevalence of 10.3%
of persons over age 65 in USA.在美国
10.3%超过65岁老人患有老年性痴呆。
delirium [d?'l?r??m]
n. 精神错乱；发狂，狂热；说谵语状态 differ from
与?不同；区别于? consciousness ['k?n??sn?s] n. 意识；知觉；觉悟；感觉
dysfunction [d?s'f??(k)?(?)n] n. 功能紊乱；机能障碍；官能不良 vi. 功能失调；出现机能障碍；垮掉
epidemiology [,ep?di:m?'?l?d??] n. 流行病学；传染病学 late-onset ['leit?nset] adj. 晚发性的；迟发性的
onset [' ? nset]
n. 开始，着手；发作；攻击，进攻
early-onset
早发型
prevalence ['prev(?)l(?)ns; 'prev?l(?)ns;
'prev?l?ns]
n. 流行；普遍；广泛
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